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Product details for c-erbB-3/HER-3 (Human) antibody
c-erbB-3/HER-3 (Human) antibody
Overview
| Antigen: | C-erbB-3/HER-3 |
| Antibody Type: | Polyclonal |
| Application: | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 324,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN142010 |
| Availability: | 7 to 10 days until shipment |
Additional Information: c-erbB-3/HER-3 (Human) antibody
| Antigen | C-erbB-3/HER-3 |
| Immunogen | A synthetic peptide (aa 71-86) from the ligand binding domain (corresponding to aa AMNEFSTLPLPNLRVV-Cys) of human c-erbB-3/HER-3 oncoprotein |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Format | Liquid |
| Description | The gene for c-erbB-3/HER-3 is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6.2kb mRNA which is translated into a 160/180kD glycoprotein. The cerbB-3/HER-3 gene encodes secreted as well as transmembrane receptor tyrosine kinase due to alternative splicing. The c-erbB-3 is overexpressed in a variety of tumors including breast, stomach, pancreas, and colon. |
| Host | Rabbit |
Application Details: c-erbB-3/HER-3 (Human) antibody
| Application | Immunohistochemistry ((Frozen Sections) (IHC) (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB) |
| Application Notes | Immunoprecipitation(1), Western Blotting (Not suitable), Immunohistology (Formalin/paraffin)(Ab. 10-20 micrograms/ml 30 Min. RT). No special pretreatment is required for immuno-histochemical staining of formalin-fixed tissues. This antibody is suitable for immunoprecipitation. The antibody also immunoprecipitates a 90kD soluble c-erbB-3 receptor from the conditioned medium of ovarian cancer cells(1). This soluble c-erbB-3 receptor is not detected by an antibody directed against the kinase domain of c-erbB-3) |
| Concentration | 1 mg/ml |
| Buffer | Total IgG purified from rabbit antiserum by Protein A chromatography and prepared at 1mg/ml in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. |
| Storage | Store at 4 C. Do not freeze. |
| Restrictions | For research use only |
External Information: c-erbB-3/HER-3 (Human) antibody
| Google Scholar | Find more references for antigen c-erbB-3/HER-3 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen c-erbB-3/HER-3 (Bioinformatic Harvester (EMBL)) |
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