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Product details for c-kit (12A8) (Human) antibody
c-kit (12A8) (Human) antibody
Overview
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| Antigen: | C-kit (12A8) |
| Antibody Type: | Monoclonal |
| Application: | Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Neutralizing (Neut) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 315,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN180067 |
| Availability: | 10 days until shipment |
Additional Information: c-kit (12A8) (Human) antibody
| Antigen | C-kit (12A8) |
| Immunogen | Recombinant protein of extracellular domain of human c-Kit |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | The proto-oncogene c-kit encodes a transmembrane tyrosine kinase receptor, and its ligand for c-Kit receptor has been identified as the stem cell factor (SCF). Recent experimental studies have shown that c-Kit plays a key role in the development of a component of the pacemaker system that is required for generation of autonomic gut motility. These studies further suggest that interaction of the c-Kit and SCF is essential for development of enteric nervous system. Recently, it is reported that the c-Kit may be an important marker for gastrointestinal stromal tumors (GISTs) which may originate from the interstitial cells of Cajal (ICCs). This monoclonal antibody recognizes c-Kit by W.B. and I.P. applications and it enables FACS analysis of c-Kit-expressing cells. It has been confirmed that the addition of this antibody does not induce ligand-binding-dependent phosphorylation of c-Kit and it may be used as a neutralizing antibody. |
| Clone | 12A8 |
| Host | Mouse |
| Specificity | Confirmed by western blotting with SY cell. |
Application Details: c-kit (12A8) (Human) antibody
| Application | Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Neutralizing (Neut) |
| Application Notes | This antibody can be used for western blotting at 1-5 ug/mL. This antibody can be used for immunoprecipitation at 3-5 ug/mL. |
| Purification | Protein A |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05%NaN3 . Reconstitution: 1.0 mL deionized water will be added to the product |
| Storage | Lyophilized product, 5 years at 2 8 : Solution, 2 years at 20 |
| Research Area | Proliferation Markers |
| Restrictions | For Research Use only |
External Information: c-kit (12A8) (Human) antibody
| Google Scholar | Find more references for clone 12A8 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen c-kit (12A8) (Bioinformatic Harvester (EMBL)) |
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