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Product details for p14ARF (Human) antibody
p14ARF (Human) antibody
Overview
| Antigen: | P14 ARF (C-term) |
| Antibody Type: | Polyclonal |
| Application: | Immunofluorescence (IF), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Rabbit |
| Quantity: | |
| Price: | 300,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN152299 |
| Availability: | Ships in 7 to 10 days |
Additional Information: p14ARF (Human) antibody
| Antigen | P14 ARF (C-term) |
| Immunogen | A synthetic peptide to human p14ARF (C-terminal sequence). |
| Reactivity | Human |
| Antibody Type | Polyclonal |
| Format | Aff - Purified |
| Description | The INK4a-ARF locus is comprised of two tumor suppressors, p16INK4a and p14ARF. These two proteins are encoded through differential splicing of alternative first exons. The p16INK4a (exon 1alpha) protein inhibits the cyclin D-dependent kinases (CDK) thatcontrol the phosphorylation of the Rb protein and cell proliferation. The p14ARF geneproduct complexes with the MDM2 protein within the nucleus, thus modulating theactivity of the p53 protein. P14ARF is a potent tumor suppressor in the presence ofwild-type p53, while mutant p53 substantially reduces growth inhibition by p14ARF. Synonyms: ARF antibody, CDK4 inhibitor p16INK4 antibody, CDK4I antibody, CDKN2 antibody,CDKN2A antibody, Cell cycle negative regulator beta antibody, CMM2 antibody, Cyclindependent kinase inhibitor 2A antibody, Cyclin dependent kinase inhibitor p16 antibody,INK4 antibody, INK4a antibody, MLM antibody, MTS1 antibody, Multiple tumorsuppressor 1 antibody, p14 antibody, p16 antibody, p16INK4 antibody, TP16 antibody |
| Host | Rabbit |
| Specificity | This antibody is specific for p14ARF. This antibody reacts with human p14ARF. Other species untested. |
Application Details: p14ARF (Human) antibody
| Application | Immunofluorescence (IF), Western Blotting (WB) |
| Application Notes | This antibody may be used for Western blotting where a band is seen at ~14 kDarepresenting p14ARF. In addition, this antibody may be used for immunofluorescence.Suggested working dilutions: *Western Blot 1:1000 (ECL)ImmunofluorescenceTBD*The investigator should determine the optimal working dilution for a specific application. Positive Control:BT549 or HeLa (NB800-PC1) whole cell extracts |
| Buffer | 100 ul affinity purified rabbit antisera in PBS and 0.1% Sodium Azide. Proteinconcentration is 1.0 mg/ml. |
| Storage | Store at 20 degrees Celcius. Avoid repeated freeze-thaw cycles. |
| Restrictions | For Research Use only |
External Information: p14ARF (Human) antibody
| Google Scholar | Find more references for antigen p14 ARF (C-term) on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen p14 ARF (C-term) (Bioinformatic Harvester (EMBL)) |
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