BASKET
HELP
Product details for v-erb-b2 erythroblastic leukemia viral oncogene homolog 3...
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) (Human) antibody
Overview
|
|
| Antigen: | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) |
| Antibody Type: | Monoclonal |
| Application: | Western Blotting (WB), ELISA |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 396,00 € (Plus shipping costs , €10.00 dry ice fee and VAT) |
| Order number: | ABIN166174 |
| Availability: | Delivery in 7 to 10 days |
Additional Information: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) (Human) antibody
| Antigen | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) |
| Gene ID | 2065 |
| Immunogen | ERBB3 (AAH02706, 1 a.a. ~ 131 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence: (without GST) MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYER CEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQV YDGKFAIFVMLNYNTNSSHA* |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Isotype | IgG1 kappa »Matching secondary antibodies |
| Description | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. Mouse monoclonal antibody raised against a partial recombinant ERBB3. Synonyms: ErbB-3, HER3, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3 |
| Clone | 2000000000 |
| Host | Mouse |
Application Details: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) (Human) antibody
| Application | Western Blotting (WB), ELISA |
| Application Notes | Quality Control: Antibody Reactive Against Recombinant Protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control. |
| Buffer | In 1x PBS, pH 7.2 Western Blot detection against Immunogen (40.41 KDa) . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Restrictions | For Research Use only |
Images: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) (Human) antibody
|
Western Blot detection against Immunogen (40.41 KDa) . |
External Information: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) (Human) antibody
| Google Scholar | Find more references for clone 2000000000 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen ERBB3 (Bioinformatic Harvester (EMBL)) |
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
