Quantity: 100 µg. Format: Liquid. Description: DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, genetic imprinting, and X-chromosome inactivation. Hypermethylation of DNA has also been implicated in tumorigenesis ... Immunogen: Synthetic peptide: MKGDSRHLNEE... Specificity: This antibody detects DNA methyltransferase 3b (Dn...  More »

Quantity: 50 µl. Description: Reversible acetylation of highly conserved lysine residues in N-terminal tail domains of core histones plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone acetylation is a dynamic process determined by the net activ... Immunogen: Synthetic peptide: C-KEEKPEAKG... Specificity: Anti-Histone Deacetylase 1 specifically recognizes...  More »

Quantity: 100 µg. Description: HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a ... Immunogen: Unfortunately, this informatio... Specificity: The antibody detects ~140 kDa histone deacetylase ...  More »

Quantity: 100 µg. Format: Liquid. Description: HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in t... Specificity: The antibody detects ~105 kDa histone deacetylase ...  More »

Quantity: 50 µg. Clone: 0-T-60. Format: Liquid. Description: Although histones are classified into a limited number of types of fractions with each particular fraction having a fundamentally distinct amino acid composition and sequence, numerous subfractions are observed due to the acetylation, methylation, and phosphorylation of vari... Immunogen: Nuclei from myeloid leukemia b... Specificity: Doublet detected due to hyper-phosphorylation of h...  More »

Quantity: 100 µl. Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3... Immunogen: Synthetic peptide: KQLATKAcAAR...  More »

Quantity: 50 µg. Format: Liquid. Description: Rabbit polyclonal to Maf -ChIP Grade Immunogen: Immunogen was a synthetic pept...  More »

Quantity: 100 µg. Description: Methyl CpG binding domain proteins (MBDs) are a family of mammalian proteins that specifically bind methylated regions of DNA. There are two methyl CpG binding complexes, MeCP1 and MeCP2. MeCP2 is comprised of a single protein also denoted MeCP2. MeCP1 is composed of four di... Immunogen: Synthetic peptide: C-RSKDLKKPG... Specificity: This antibody detects human methyl CpG binding dom...  More »

Quantity: 100 µg. Clone: 1212. Format: Liquid. Description: Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription fa... Immunogen: Synthetic peptide: CGGA-SASDPH...  More »

Quantity: 100 µg. Description: Arginine methylation is an irreversible post translational modification that has only recently been linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions ... Immunogen: Synthetic peptide: AIADYAATDET...  More »