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Product details for PECAM 1 antibody (Human)
PECAM 1 antibody (Human)
Overview
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| Antigen: | PECAM-1 |
| Antibody Type: | Monoclonal |
| Application: | Immunohistochemistry (IHC), Western Blotting (WB) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 515,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN108424 |
| Availability: | 1 to 2 weeks |
Additional Information: PECAM 1 antibody (Human)
| Antigen | PECAM-1 |
| Immunogen | Monoclonal antibody to PECAM-1 is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Ulex Europaeus-agglutinin-I reactive glycoproteins from cultured human umbilical vein endothelial cells isolated by lecitin-affinity chromatography were used as immunogen |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Purified |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | PECAM-1 (CE6) monoclonal antibody against PECAM-1 was produced to characterize human leukemic cells. PECAM-1 is typically an antigen that is shared by both endothelial and distinct hematopoietic cells. It is widely expressed among leukocytes and functions as cell adhesion molecule for these cells. PECAM-1 reactivity can be interpreted as a further evidence for megakaryocytic nature of distinct cell lines has been shown. However, a new useful application for this monoclonal antibody appears to be its very high reactivity against human endothelial cells. A recent review article states that in contrast to other applied endothelial markers, for instance PAL-E monoclonal antibody to endothelial cells and antibodies to factor VIII-related antigen, CE6 monoclonal antibody, reacts with all endothelial cells in human breast. |
| Clone | CE6 |
| Host | Mouse |
| Specificity | The antibody reacts with Mr 135 000 PECAM-1 polypeptide from leukocytes and endothelial cells. Detects all endothelial cells in breast. Shows erythroid differentiation in human leukemic cells. |
Application Details: PECAM 1 antibody (Human)
| Application | Immunohistochemistry (IHC), Western Blotting (WB) |
| Application Notes | No reactivity with paraffin sections. Working dilution in western blotting is at least 1:1000 |
| Storage | This product should be stored at +2 C to +8 C |
| Research Area | Extracellular Matrix |
| Restrictions | Research only |
Publications: PECAM 1 antibody (Human)
| Publications |
Tani T, Ylanne J, Virtanen I: "Expression of megakaryocytic and erythroid properties in human leukemic cells." In: Exp Hematol , Vol. 24, Issue 2, pp. 158-68, 1996/02 (PubMed) Ronnov-Jessen L, Petersen OW, Bissell MJ: "Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction." In: Physiol Rev , Vol. 76, Issue 1, pp. 69-125, 1996/01 (PubMed) |
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