BASKET
HELP
Product details for Insulin Receptor beta (Human) antibody
Insulin Receptor beta (Human) antibody
Overview
| Antigen: | Insulin Receptor beta |
| Antibody Type: | Monoclonal |
| Application: | Enzyme Immunoassay (EIA), Immunoprecipitation (IP) |
| Reactivity: | Human, Mouse (Murine), Rat |
| Host: | Mouse |
| Quantity: | |
| Price: | 271,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN145243 |
| Availability: | 7 to 10 days until shipment |
Additional Information: Insulin Receptor beta (Human) antibody
| Antigen | Insulin Receptor beta |
| Immunogen | Synthetic peptide: GKKNGRILTLPRSNPS, corresponding to amino acids 1367-1382 of Human Insulin Receptor. |
| Reactivity | Human, Mouse (Murine), Rat |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | IR is a receptor tyrosine kinase which mediates the biological activities of insulin by regulating multiple signaling pathways through activation of a series of phosphorylation cascades. The receptor is a disulfide linked heterotetrameric glycoprotein consisting of two alpha subunits and two beta subunits arranged in the following configuration: beta-alpha-alpha-beta. The alpha subunits each contain insulin binding sites and are entirely extracellular in localization. The beta subunits each possess an extracellular domain, a single transmembrane domain, and a cytoplasmic tyrosine kinase domain. Binding of insulin to the alpha subunits induces a conformation change in the receptor which activates the kinase domain, stimulating tyrosine autophosphorylation of the receptor and tyrosine phosphorylation of at least five different insulin receptor substrates designated IRS-1-4, and Shc. |
| Clone | CT-1 |
| Host | Mouse |
| Specificity | This antibody is specific for the approximately 95 kDa IR and shows no cross-reactivity with insulin like growth factor (IGF) receptors. Phosphorylation of the threonine residue within this sequence (corresponding to threonine 1348) decreases the affinity |
Application Details: Insulin Receptor beta (Human) antibody
| Application | Enzyme Immunoassay (EIA), Immunoprecipitation (IP) |
| Application Notes | EIA: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | 0.2 mg/ml |
| Purity | Protein G purified |
| Buffer | Preservative: 0.09% Sodium AzideConstituents: 0.2% BSA, PBS. pH 7.4 |
| Restrictions | For research use only |
External Information: Insulin Receptor beta (Human) antibody
| Google Scholar | Find more references for clone CT-1 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen Insulin Receptor beta (Bioinformatic Harvester (EMBL)) |
browse antibodies by
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
Antigens
Secondary Antibodies
Research areas
Clones
Hosts
Applications
Reactivity
Supplier
