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Product details for DR5 (Human) antibody
DR5 (Human) antibody
Overview
| Antigen: | DR5 |
| Antibody Type: | Monoclonal |
| Application: | Functional Studies (FUNC) |
| Reactivity: | Human |
| Host: | Mouse |
| Quantity: | |
| Price: | 180,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN94304 |
| Availability: | 1 to 3 days until shipment |
Additional Information: DR5 (Human) antibody
| Antigen | DR5 |
| Immunogen | Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5. |
| Reactivity | Human |
| Antibody Type | Monoclonal |
| Format | Purified |
| Isotype | IgG1 »Matching secondary antibodies |
| Clone | DR5-01 |
| Host | Mouse |
| Specificity | The antibody recognizes extracellular domain of DR5. Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. |
Application Details: DR5 (Human) antibody
| Application | Functional Studies (FUNC) |
| Application Notes | The Applications are presented only at purified format of antibody. |
| Concentration | 1 mg/ml |
| Purity | > 95% (by SDS-PAGE) |
| Purification | Purified from hybridoma culture supernatant by protein A-affinity chromatography. |
| Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Storage | Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles. |
| Research Area | Apoptosis/Necrosis |
| Restrictions | For Research Use only |
External Information: DR5 (Human) antibody
| Google Scholar | Find more references for clone DR5-01 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen DR5 (Bioinformatic Harvester (EMBL)) |
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