MAGE 1 (Human) antibody

Overview

Antigen	MAGE 1
Immunogen	Recombinant full length protein (Human).
Reactivity	Human
Antibody Type	Monoclonal
Format	Liquid
Isotype	IgG2a »Matching secondary antibodies
Description	Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE 1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Clone	E22-11B2-E9
Host	Mouse

Application	Western Blotting (WB)
Application Notes	Western Blotting: use at a concentration of 1-2ug / ml for 2hrs at RT. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects a band of 42-46 kDa, which corresponds to the predicted molecular weight of MAGE 1.
Concentration	0.2 mg/ml
Purity	Protein A purified
Buffer	10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide
Storage	Refrigerate at 4 C. Do not freeze.
Restrictions	For research use only

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EMBL Harvester	Search human, mouse or rat genome for antigen MAGE 1 (Bioinformatic Harvester (EMBL))