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Product details for MAP2 (Human) antibody
MAP2 (Human) antibody
Overview
| Antigen: | MAP2 |
| Antibody Type: | Monoclonal |
| Application: | Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB) |
| Reactivity: | Human, Mouse (Murine), Rat, Bovine |
| Host: | Mouse |
| Quantity: | |
| Price: | 247,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN144443 |
| Availability: | 7 to 10 days until shipment |
Additional Information: MAP2 (Human) antibody
| Antigen | MAP2 |
| Immunogen | Rat brain microtubule associated proteins (MAPs). |
| Reactivity | Human, Mouse (Murine), Rat, Bovine |
| Antibody Type | Monoclonal |
| Format | Liquid |
| Isotype | IgG1 »Matching secondary antibodies |
| Description | MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2, two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton. |
| Clone | HM-2 |
| Host | Mouse |
| Specificity | Monoclonal Anti-MAP2 does not react with tubulin of other microtubule associated proteins. |
Application Details: MAP2 (Human) antibody
| Application | Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB) |
| Application Notes | ICC: Use at an assay dependent dilution. IHC: Use at an assay dependent dilution. WB: Use at a concentration of 1-2 ug/ml. This concentration is recommended using a rat brain extract. Detects a band of approximately 280 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Concentration | Batch Dependent |
| Purity | Protein A purified |
| Buffer | Preservative: 15mM Sodium AzideConstituents: 0.01M PBS. pH 7.4 |
| Restrictions | For research use only |
External Information: MAP2 (Human) antibody
| Google Scholar | Find more references for clone HM-2 on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen MAP2 (Bioinformatic Harvester (EMBL)) |
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