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Browse our CACNA1H Proteins (CACNA1H)

Full name:
Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit Proteins (CACNA1H)
On www.antibodies-online.com are 9 Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) Proteins from 2 different suppliers available. Additionally we are shipping CACNA1H Antibodies (62) and CACNA1H Kits (4) and many more products for this protein. A total of 75 CACNA1H products are currently listed.
Synonyms:
alpha13.2, CACNA1HB, Cav3.2, ECA6, EIG6, MNCb-1209
list all proteins Gene Name GeneID UniProt
CACNA1H 8912 O95180
CACNA1H 58226  
Rat CACNA1H CACNA1H 114862 Q9EQ60

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CACNA1H Proteins (CACNA1H) by Origin

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Human Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) interaction partners

  1. There is a direct link between CACNA1H(M1549V) mutation and an increased aldosterone production. This suggests that calcium channel blockers may be beneficial in the treatment of a subset of patients with primary aldosteronism.

  2. CACNA1H might be a susceptibility gene predisposing to PA with different phenotypic presentations, opening new perspectives for genetic diagnosis and management of patients with PA.

  3. heterozygous mutations identified in a pediatric patient with chronic pain and absence seizures result in loss of channel function, with significantly smaller current densities across a wide range of voltages when co-expressed in tsA (show PRDX2 Proteins)-201 cells.

  4. CaV3.1 (show CACNA1G Proteins), CaV3.2 and CaV3.3 (show CACNA1I Proteins) channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons.

  5. Study revealed no association between the 15 tagSNPs of CACNA1A (show CACNA1A Proteins), 1C, and 1H and antiepileptic drug efficacy in the Chinese Han epileptic population; the TAGAA haplotype of CACNA1A (show CACNA1A Proteins) may be a risk factor for drug resistance

  6. Cav3.2 channels are highly phosphorylated in the mammalian brain and establish phosphorylation as an important mechanism involved in the dynamic regulation of Cav3.2 channel gating properties

  7. Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism.

  8. reveal an unexpected role of CaV3.2 channels in regulating NMDA-R-mediated transmission and a novel epileptogenic mechanism for human childhood absence epilepsy

  9. The I-II loop of the Cav3.2 protein inhibits neuronal Cav3.1 (show CACNA1G Proteins) and Cav3.2 channels.

  10. N-linked glycosylation of Cav3.2 not only controls surface expression.

Mouse (Murine) Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) interaction partners

  1. findings suggest that chronic intermittent hypoxia leads to an augmented calcium influx via reactive oxygen species -dependent facilitation of CaV3.2 protein trafficking to the plasma membrane.

  2. these data show that CaV3.2 T-type channels have prev8iously unrecognized roles in supporting the meiotic-maturation-associated increase in ER Ca(2 (show CA2 Proteins)+) stores and mediating Ca(2 (show CA2 Proteins)+) influx required for the activation of development.

  3. MTF1 (show MTF1 Proteins) mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.

  4. both suramin and gossypetin produced dose-dependent and long-lasting mechanical anti-hyperalgesia that was abolished or greatly attenuated in Cav3.2 null mice

  5. Data show increased expression of T-type Ca(2 (show CA2 Proteins)+) current and association of protein kinase C alpha (PKCalpha (show PKCa Proteins)) with caveolin-3 (Cav-3 (show CAV3 Proteins))was disrupted in the hypertrophic ventricular myocyte.

  6. the asymmetric effects of the Cav3.2 and its partial reversal by behavior training on the hippocampal transcriptome

  7. This study demonstrated that CaV3.2 KO mice have altered retinal waves but normal direction selectivity.

  8. Suggest a negative feedback mechanism of the myogenic response in which CaV3.2 channel modulates downstream ryanodine receptor (show RYR3 Proteins)-BKCa (show KCNMA1 Proteins) to hyperpolarize and relax arteries.

  9. our results indicate that inhibition of Cav3 (show CAV3 Proteins) currents by 5,6-epoxyeicosatrienoic acid is an important mechanism controlling the vascular tone.

  10. NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 (show CNR2 Proteins) receptors

CACNA1H Protein Profile

Protein Summary

This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).

Alternative names and synonyms associated with CACNA1H

  • calcium channel, voltage-dependent, T type, alpha 1H subunit (CACNA1H)
  • calcium channel, voltage-dependent, T type, alpha 1H subunit (Cacna1h)
  • alpha13.2 protein
  • CACNA1HB protein
  • Cav3.2 protein
  • ECA6 protein
  • EIG6 protein
  • MNCb-1209 protein

Protein level used designations for CACNA1H

calcium channel, voltage-dependent, T type, alpha 1Hb subunit , low-voltage-activated calcium channel alpha1 3.2 subunit , low-voltage-activated calcium channel alpha13.2 subunit , voltage dependent t-type calcium channel alpha-1H subunit , voltage-dependent T-type calcium channel subunit alpha-1H , voltage-gated calcium channel alpha subunit Cav3.2 , voltage-gated calcium channel alpha subunit CavT.2 , voltage-gated calcium channel subunit alpha Cav3.2 , T-type Cav3.2 , calcium channel alpha13.2 subunit

GENE ID SPECIES
8912 Homo sapiens
58226 Mus musculus
114862 Rattus norvegicus
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