Browse our Adenosine A2b Receptor Proteins (ADORA2B)

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Adenosine A2b Receptor Proteins (ADORA2B)
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Synonyms:
A2b, A2BAR, A2BR, AA2BR, ADORA2, ADORA2B, AI480866, AI605384, LOC606745, LOC100220469, si:dkey-13b16.1
list all proteins Gene Name GeneID UniProt
ADORA2B 136 P29275
Rat ADORA2B ADORA2B 29316 P29276
ADORA2B 11541 Q60614

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Adenosine A2b Receptor Proteins (ADORA2B) by Origin

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More Proteins for Adenosine A2b Receptor Interaction Partners

Zebrafish Adenosine A2b Receptor (ADORA2B) interaction partners

  1. activation of PPARalpha (show PPARA Proteins) promoted angiogenesis just as activation of A2B receptors through an epoxide dependent mechanism

Pig (Porcine) Adenosine A2b Receptor (ADORA2B) interaction partners

  1. mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Proteins)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Proteins)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells

Human Adenosine A2b Receptor (ADORA2B) interaction partners

  1. The A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS (show ROS1 Proteins) production in colorectal cancer cells via adenosine receptor-independent mechanism.

  2. the effects of TNF-alpha (show TNF Proteins) were investigated on the expression/responsiveness of the A2B adenosine receptor (A2BAR), a Gs-coupled receptor that promotes mesenchymal stem cell (MSC (show MSC Proteins)) differentiation into osteoblasts.

  3. Actinin (show ACTN1 Proteins)-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression

  4. cells lacking A2b do not respond in this manner to hypoxia or ATP but transfection of A2b restores this response, that Epac1 (show RAPGEF3 Proteins) is critically involved, and that Rap1B (show RAP1B Proteins) is important for the relative positioning of the centrosome and nucleus.

  5. Studies show that A2b receptor is overexpressed in various tumor lines and biopsies from patients with different cancers. This suggests that A2b receptor can be used by tumor cells to promote progression. [review]

  6. Findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population.

  7. erythrocyte AMP-activated protein kinase (show PRKAA2 Proteins) was activated in humans at high altitude. It is a key protein functioning downstream of the A2B adenosine receptor, phosphorylating and activating BPG mutase and thus inducing 2,3-BPG production and O2 release from erythrocytes.

  8. A2B receptor activation is critically required for the stimulatory effect of adenosine on IL-10 (show IL10 Proteins) production and suppression of nitric oxide release.

  9. Data show that ADORA2B mRNA and protein were significantly up-regulated in oral squamous cell carcinoma (OSCC) and that ADORA2B controls cellular proliferation via HIF-1alpha (show HIF1A Proteins) activation, suggesting it may be a key regulator of tumoral progression in OSCCs.

  10. ADORA2B is a target gene of miR (show MLXIP Proteins)-128b.MiR-128b represses cell proliferation, migration and invasion and promotes apoptosis by targeting ADORA2B in gastric cancer.

Mouse (Murine) Adenosine A2b Receptor (ADORA2B) interaction partners

  1. It has been reported that signaling through hepatocellular Adora2b adenosine receptors dampens IR injury of the liver.

  2. Diabetes resulted in an increased A2A/A2B receptor expression in coronary arteries which resulted in enhanced A2A/A2B-mediated increase in coronary flow observed in diabetic hearts.

  3. A2B adenosine receptor-induced VEGF production and angiogenesis are involved in myeloid-derived suppressor cells in a mouse melanoma model

  4. Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors

  5. our results suggest that intestinal epithelial Adora2b signaling provides protection during intestinal inflammation via enhancing mucosal barrier responses.

  6. exposure of DCs to A2BR agonist facilitated gammadelta T cell activation, leading to augmented Th17 responses and progressive EAU development.

  7. IFN-gamma (show IFNG Proteins) priming of macrophages selectively prevents the induction of the A2bR in macrophages to mitigate sensitivity to adenosine and to prevent this regulatory transition.

  8. These findings implicate that tissue-specific targeting of Adora2b seems to be desirable when using Adora2b agonists to prevent or treat myocardial ischemia.

  9. alveolar epithelial A2B adenosine receptor signaling contributes to lung protection, and they implicate inhaled A2B adenosine receptor agonists in ALI treatment.

  10. the adenosine A2b receptor was shown to be the only one of the adenosine receptors whose cardiac expression is induced by ischemia in both mice and humans and whose function is implicated in ischemic pre- or post-conditioning

Cow (Bovine) Adenosine A2b Receptor (ADORA2B) interaction partners

  1. Purinergic stimulation of cilia beat frequency requires A(2B (show ADRA2B Proteins)) adenosine receptor activation, likely via protein kinase A-dependent pathway.

  2. It is likely that adenosine acts through A(2B (show ADRA2B Proteins)) receptors and adenylyl cyclases to stimulate CNGA2 (show CNGA2 Proteins).

Rabbit Adenosine A2b Receptor (ADORA2B) interaction partners

  1. Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Proteins)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.

Adenosine A2b Receptor (ADORA2B) Protein Profile

Protein Summary

This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17.

Alternative names and synonyms associated with Adenosine A2b Receptor (ADORA2B)

  • adenosine A2b receptor (adora2b)
  • adenosine A2b receptor (ADORA2B)
  • A2b adenosine receptor (LOC606745)
  • adenosine A2b receptor (LOC100220469)
  • adenosine A2B receptor (Adora2b)
  • adenosine A2b receptor (Adora2b)
  • A2b protein
  • A2BAR protein
  • A2BR protein
  • AA2BR protein
  • ADORA2 protein
  • ADORA2B protein
  • AI480866 protein
  • AI605384 protein
  • LOC606745 protein
  • LOC100220469 protein
  • si:dkey-13b16.1 protein

Protein level used designations for ADORA2B

adenosine receptor A2b , adenosine A2b receptor , A2b adenosine receptor , adenosine receptor A2b-like , A2b, Rs , adenosine receptor 2b , A2B adenosine receptor

GENE ID SPECIES
560100 Danio rerio
455009 Pan troglodytes
696848 Macaca mulatta
606745 Sus scrofa
100220469 Taeniopygia guttata
100448500 Pongo abelii
136 Homo sapiens
29316 Rattus norvegicus
403410 Canis lupus familiaris
11541 Mus musculus
529760 Bos taurus
395971 Gallus gallus
100008951 Oryctolagus cuniculus
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