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activation of PPARalpha (show PPARA Proteins) promoted angiogenesis just as activation of A2B receptors through an epoxide dependent mechanism
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Proteins)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Proteins)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Studies show that A2b receptor is overexpressed in various tumor lines and biopsies from patients with different cancers. This suggests that A2b receptor can be used by tumor cells to promote progression. [review]
Findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population.
erythrocyte AMP-activated protein kinase (show PRKAA2 Proteins) was activated in humans at high altitude. It is a key protein functioning downstream of the A2B adenosine receptor, phosphorylating and activating BPG mutase and thus inducing 2,3-BPG production and O2 release from erythrocytes.
A2B receptor activation is critically required for the stimulatory effect of adenosine on IL-10 (show IL10 Proteins) production and suppression of nitric oxide release.
Data show that ADORA2B mRNA and protein were significantly up-regulated in oral squamous cell carcinoma (OSCC) and that ADORA2B controls cellular proliferation via HIF-1alpha (show HIF1A Proteins) activation, suggesting it may be a key regulator of tumoral progression in OSCCs.
ADORA2B is a target gene of miR (show MLXIP Proteins)-128b.MiR-128b represses cell proliferation, migration and invasion and promotes apoptosis by targeting ADORA2B in gastric cancer.
the A2B AR activation-driven angiogenesis via cAMP-PKA-CREB (show CREB1 Proteins) mediates VEGF (show VEGFA Proteins) production and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)-dependent upregulation of eNOS (show NOS3 Proteins) in HMEC-1
The rs7208480 of ADORA2B as well as the haplotypes were not found to be associated with chronic heart failure susceptibility.
our data suggest that adenosine A2b signaling represses CIITA (show CIITA Proteins) transcription in VSMCs by manipulating the interaction between STAT1 (show STAT1 Proteins) and the epigenetic machinery.
Stimulation of A1AR and A2BAR had a prominent anti-proliferative/pro-apoptotic effect on the glioblastoma stem cells.
Diabetes resulted in an increased A2A/A2B receptor expression in coronary arteries which resulted in enhanced A2A/A2B-mediated increase in coronary flow observed in diabetic hearts.
A2B adenosine receptor-induced VEGF production and angiogenesis are involved in myeloid-derived suppressor cells in a mouse melanoma model
Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors
our results suggest that intestinal epithelial Adora2b signaling provides protection during intestinal inflammation via enhancing mucosal barrier responses.
exposure of DCs to A2BR agonist facilitated gammadelta T cell activation, leading to augmented Th17 responses and progressive EAU development.
IFN-gamma (show IFNG Proteins) priming of macrophages selectively prevents the induction of the A2bR in macrophages to mitigate sensitivity to adenosine and to prevent this regulatory transition.
These findings implicate that tissue-specific targeting of Adora2b seems to be desirable when using Adora2b agonists to prevent or treat myocardial ischemia.
alveolar epithelial A2B adenosine receptor signaling contributes to lung protection, and they implicate inhaled A2B adenosine receptor agonists in ALI treatment.
the adenosine A2b receptor was shown to be the only one of the adenosine receptors whose cardiac expression is induced by ischemia in both mice and humans and whose function is implicated in ischemic pre- or post-conditioning
activation of the ADORA2B on macrophages plays an active role in the pathogenesis of lung fibrosis and pulmonary hypertension
Purinergic stimulation of cilia beat frequency requires A(2B (show ADRA2B Proteins)) adenosine receptor activation, likely via protein kinase A-dependent pathway.
It is likely that adenosine acts through A(2B (show ADRA2B Proteins)) receptors and adenylyl cyclases to stimulate CNGA2 (show CNGA2 Proteins).
Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Proteins)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17.
adenosine receptor A2b
, adenosine A2b receptor
, A2b adenosine receptor
, adenosine receptor A2b-like
, A2b, Rs
, adenosine receptor 2b
, A2B adenosine receptor