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Mouse (Murine) beta 2 Adrenergic Receptor ELISA Kit for Sandwich ELISA - ABIN427043
Zapater, Gómez-Hurtado, Peiró, González-Navajas, García, Giménez, Moratalla, Such, Francés: Beta-adrenergic receptor 1 selective antagonism inhibits norepinephrine-mediated TNF-alpha downregulation in experimental liver cirrhosis. in PLoS ONE 2012
Zebrafish larvae lacking beta1AR (show ADRB1 ELISA Kits) expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (show SCP2 ELISA Kits)), a form of synaptic plasticity that requires Cav1.2 (show CACNA1C ELISA Kits) and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade.
activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP (show APP ELISA Kits) at Thr668
Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin (show INS ELISA Kits)-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes
beta2-AR deletion is associated to selective hepatic insulin (show INS ELISA Kits) resistance and preserved skeletal muscle insulin (show INS ELISA Kits) sensitivity.
The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped.
knocking out of the beta1/2 (show TFAP2B ELISA Kits) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.
The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 (show CACNA1C ELISA Kits) upon beta-adrenergic stimulation rendering Cav1.2 (show CACNA1C ELISA Kits) refractory for several minutes from further beta-adrenergic stimulation.
The Galphas (show GNAS ELISA Kits) and Galphaq (show GNAQ ELISA Kits) peptides adopt different orientations in beta2-AR and V1AR (show AVPR1A ELISA Kits), respectively. The beta2-AR/Galphas (show GNAS ELISA Kits) peptide interface is dominated by electrostatic interactions, whereas the V1AR (show AVPR1A ELISA Kits)/Galphaq (show GNAQ ELISA Kits) peptide interactions are predominantly hydrophobic.
Thus the beta2AR acts as a double-edged sword: increasing TAS2R14 cell surface expression, but when activated by beta-agonist, partially offsetting the expression phenotype by direct receptor:receptor desensitization of TAS2R14 function.
Data show that inhibitory (Galphai2 (show GNAI2 ELISA Kits)) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 (show GNAI2 ELISA Kits) over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.
These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor (show NR3C1 ELISA Kits) with neonatal glucose and lipid metabolism.
ADRb2 shows lipid scrambling activity.
relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R (show OXTR ELISA Kits)) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
a substantial proportion of the beta2AR produced is non-functional and VCP (show vcp ELISA Kits) plays a key role in the maturation and trafficking of the beta2AR.
The protein kinase (show CDK7 ELISA Kits) activity of PI3K (show PIK3CA ELISA Kits) phosphorylates serine residue 70 on Src (show SRC ELISA Kits) to enhance its activity and induce EGFR (show EGFR ELISA Kits) transactivation following betaAR stimulation.
The data suggested that Arg/Arg homozygosity at codon 16 of the ADRB2 gene predisposes patients to a clinically more severe course of chronic obstructive pulmonary disease
using single-molecule fluorescence resonance energy transfer imaging, we examine TM6 movements in the beta2 adrenergic receptor (beta2AR) upon exposure to orthosteric ligands with different efficacies, in the absence and presence of the Gs heterotrimer
The frequency of the genotypes and alleles of rs1042711 in ADRB2 showed a significant difference between the COPD (show ARCN1 ELISA Kits) and control groups. TT genotype and TG and TC haplotypes of rs1042711 in ADRB2 are related to pulmonary function in COPD (show ARCN1 ELISA Kits) patients. TT genotype of rs1042711 in ADRB2 and smoking amount are risk factors for COPD (show ARCN1 ELISA Kits) development.
Results provide further evidence for the interaction of rs2400707, and other SNPs within the ADRB2 gene, with childhood trauma in relation to risk for posttraumatic stress disorder.
Gln27Glu polymorphism of ADRB2 influences exercise-induced vascular adaptation in patients with acute coronary syndrome.
Data suggest that ADRB2 (beta2 adrenergic receptor) activation (as illustrated by epinephrine and nor epinephrine) leads to robust calcium ion mobilization from intracellular stores in endoplasmic reticulum via activation of phosphoinositide phospholipase C (PLC (show PIPLC ELISA Kits)) and opening of inositol trisphosphate receptor (IP3R (show ITPR1 ELISA Kits)).
Data suggest that post-translational modifications (phosphorylation, oxidation, and nitrosylation) of RyR2 (ryanodine receptor 2 (show RYR2 ELISA Kits)) occur downstream of production of amyloid beta-peptides through ADRB2 (beta2-adrenergic receptor) Ca2 (show CA2 ELISA Kits)+ signaling cascade that activates PKA (protein kinase A).
ADRB2 SNPs might be a genetic risk factor for dyslipidemia in the Chinese hypertensive patients. the A46G polymorphism was significantly associated with the elevated risk of hypertriglyceridemia. Haplotype analysis showed that the TAC (show IL2RA ELISA Kits) haplotype carrying frequent alleles of the three SNPs played a reduced role in hypertriglyceridemia risk and the TGC (show TGM2 ELISA Kits) haplotype carrying rare allele of A46G expressed a significant risk effe
A persistent B2R (show BDKRB2 ELISA Kits)-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA (show PLAT ELISA Kits).
Prolactin (show PRL ELISA Kits) infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway
Intracoronary intermedin (show ADM2 ELISA Kits) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (show CALCA ELISA Kits) receptors and beta-adrenoreceptor-mediated nitric oxide release.
The results imply ADRB-2-mediated actions in the development of primate follicles
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
adrenergic receptor beta-2
, adrenergic, beta-2-, receptor, surface
, beta-2 adrenergic receptor
, beta-2b-adrenergic receptor
, beta-2 adrenoceptor
, beta-2 adrenoreceptor
, beta 2-AR
, adrenergic receptor beta 2
, adrenergic, beta-2, receptor, surface
, catecholamine receptor
, beta2-adrenergic receptor
, Adrenergic beta 2- receptor surface
, adrenergic receptor, beta 2
, Beta-2 adrenergic receptor
, Beta-2 adrenoceptor
, Beta-2 adrenoreceptor
, beta 2 adrenergic receptor
, beta-2-adrenergic receptor