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Data from ligand-receptor interaction studies suggest that human spexin (show C12orf39 ELISA Kits)-1 and zebrafish spexin (show C12orf39 ELISA Kits)-2 activate galanin (show GAL ELISA Kits) receptors GALR2 (show GALR2 ELISA Kits)/GALR3 (but not GALR1 (show GALR1 ELISA Kits)); thus spexins appear to be natural ligands for human/Xenopus/zebrafish GALR2 (show GALR2 ELISA Kits)/GALR3.
Variants in genes for galanin (GAL (show GAL ELISA Kits)) and its receptors (GALR1 (show GALR1 ELISA Kits), GALR2 (show GALR2 ELISA Kits), GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
The results suggest that GalR3, a receptor for the neuroendocrine peptide galanin (show GAL ELISA Kits), is a potential marker for relapsing pituitary tumors.
Mutated human GalR3 receptors are tested with competitive binding analysis in vitro, identifying six different sites in GalR3 that determine binding to galanin (show GAL ELISA Kits).
Elevated expression of galanin (show GAL ELISA Kits) receptors in childhood neuroblastic tumors.
GALR3 showed a significant association with alcoholism that was driven by one SNP (rs3,091,367).
After arthritis induction, GAL3 (show LGALS3 ELISA Kits) knockouts demonstrated increased clinical disease severity and earlier hindlimb edema than wild types.
Our data suggest involvement of GAL3 (show LGALS3 ELISA Kits) receptors in GAL (show GAL ELISA Kits)-mediated effects on mood, anxiety, and behavior.
This study shows GalR3-mediated neuroprotection, supporting a potential future therapeutic development, based on GalR3 activation, for the treatment of brain disorders
Data show that galanin (show GAL ELISA Kits) receptor mRNA and protein are expressed in mouse pancreas, with GALR3 mRNA predominating.
GalR3 is the receptor subtype mediating galanin's effects on the dermal microvasculature
Receptor for the hormone galanin.
galanin receptor type 3
, galanin receptor 3
, galanin receptor, family member 3