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anti-Mouse (Murine) GNAI2 Antibodies:
anti-Human GNAI2 Antibodies:
anti-Rat (Rattus) GNAI2 Antibodies:
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Human Polyclonal GNAI2 Primary Antibody for WB - ABIN4891909
López-Aranda, Acevedo, Gutierrez, Koulen, Khan: Role of a Galphai2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool. in Journal of cell science 2007
Human Polyclonal GNAI2 Primary Antibody for ELISA, WB - ABIN4312956
Kremer, Kumar, Hedin: G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions. in Journal of immunology (Baltimore, Md. : 1950) 2011
This study reveals how RGS (show PITX2 Antibodies) proteins modulate Galphai2 signaling to facilitate thymocyte egress and T cell trafficking.
this study shows that Galphai2 controls arrest in response to chemokine (show CCL1 Antibodies) stimulation of neutrophils
In Galphai2-knockdown mice, they showed defects in social interaction, novelty recognition and active avoidance learning.
Data show that inhibitory (Galphai2) and stimulatory (GalphasL) G-protein subunits produced minor atrophic and hypertrophic changes in muscle mass, and Galphai2 over-expression prevented AAV:beta2-adrenoceptor (beta2-AR) mediated hypertrophy.
RGS (show PITX2 Antibodies) proteins and Galphai2 play a significant role in regulating states of wakefulness, NREM sleep, and REM (show REM1 Antibodies) sleep
Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
Galphai2 deficiency combined with cardiac beta1-adrenoceptor overexpression strongly impaired survival and cardiac function, leading to dilated cardiomyopathy.
An essential role for Galpha (show SUCLG1 Antibodies)(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.
Platelet Galphai2 not only controls hemostatic and thrombotic responses but also is critical for the development of ischemia/reperfusion injury in vivo.
Data show that disrupting resistance to inhibitors of cholinesterase 8A (Ric-8A (show RIC8A Antibodies)) expression in hematopoietic cells results in a loss of GTP-binding protein (show DRG1 Antibodies) alpha subunits Galphai2, Galphai3 (show GNAI3 Antibodies), and Galphaq (show GNAQ Antibodies).
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2, and Galphai3 (show GNAI3 Antibodies), with no evidence for functional coupling to Galphagust.
Data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in ovarian carcinoma.
Galpha (show SUCLG1 Antibodies)(i2) activates the TRPC4 (show TRPC4 Antibodies) channel by direct binding.
Changes in ion selectivity and pore dilation of the TRPC4 (show TRPC4 Antibodies) channel elicited by the Galphai2 subunit, were studied.
Galphai2(Q205L) regulates satellite cell differentiation into myotubes in a protein kinase C (show PKC Antibodies) - and histone deacetylase (show HDAC1 Antibodies) -dependent manner
These results suggest that the extent of G-protein-mediated inhibition is significantly reduced in the K1336E mutant CaV2.1 (show CACNA1A Antibodies) Ca(2 (show CA2 Antibodies)+) channels
The ubiquitination of Galphai2 and Galphaq (show GNAQ Antibodies) is suppressed by expression of Ric-8A (show RIC8A Antibodies). The suppression likely requires Ric-8A (show RIC8A Antibodies) interaction with these Galpha (show SUCLG1 Antibodies) proteins; the C-terminal truncation of Galphaq (show GNAQ Antibodies) and Galphai2 completely abrogates their interaction with Ric-8A (show RIC8A Antibodies).
Gialpha2 plays an essential role in OXT (show OXT Antibodies) and EGF (show EGF Antibodies) signaling to induce prostate cancer cell migration.
HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Galpha (show SUCLG1 Antibodies)(i2) for degradation through ubiquitination
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 2
, guanine nucleotide-binding protein G(i) subunit alpha-2
, Gi2 protein alpha-subunit
, GTP-binding regulatory protein Gi alpha-2 chain
, guanine nucleotide-binding protein G(i), alpha-2 subunit
, guanine nucleotide-binding regulatory protein alpha inhibitory subunit
, Gi-alpha-2 protein
, guanidine nucleotide binding protein, (G protein) , alpha inhibiting activity polypeptide 2
, guanine nucleotide binding protein, alpha inhibiting activity polypeptide 2
, G alpha inhibitory type 2 (a)
, G alpha inhibitory type 2 (b)
, GTP-binding protein (G-alpha-i2)
, guanine nucleotide binding protein (G protein), alpha inhibiting 2
, guanine nucleotide binding protein, alpha inhibiting 3
, Galpha i2a
, guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
, guanine nucleotide-binding protein Gi2 alpha-subunit