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RACK1 emerges as an important marker of malignancy which may contribute to progress in the diagnosis of melanomas in both human and veterinary medicine.[RACK1]
Leads to the enhanced and previously un-described interaction of RACK1 and TCTP (show TPT1 ELISA Kits).
urther investigation indicated that p205 may disturb the formation of Runx2 (show RUNX2 ELISA Kits)/Ids (show IDS ELISA Kits) complex and free more Runx2 (show RUNX2 ELISA Kits) to induce the differentiation process. Taken together, our findings demonstrated for the first time that p205 functions as an activator in osteoblast differentiation.
RACK1 competes with Rab40C for binding to the ANKR2 domain of Varp (show ANKRD27 ELISA Kits) and regulates dendrite outgrowth through stabilization of Varp (show ANKRD27 ELISA Kits) in mouse melanocytes
Data show that receptor for activated C-kinase 1 (RACK1) and vascular endothelial growth factor (VEGF) expression is up-regulated after choroidal neovascularization (CNV) formation.
RACK1 is a novel factor required for adipocyte differentiation.
deficit of RACK1 in hippocampus impairs the ability of learning and memory in mice via up regulating autophagy
RACK1 plays an important role in the maintenance of morphine conditioned place preference, likely via activation of ERK (show EPHB2 ELISA Kits)-CREB (show CREB1 ELISA Kits) pathway in hippocampus.
Thr50 phosphorylation of RACK1 enhances its direct binding to Vps15, Atg14L, and Beclin 1 (show BECN1 ELISA Kits), thereby promoting the assembly of the autophagy-initiation complex.
These findings suggest that RACK1 specifies the RANKL (show TNFSF11 ELISA Kits)-stimulated activation of p38 MAPK (show MAPK14 ELISA Kits) by facilitating the association of MKK6 (show MAP2K6 ELISA Kits) with TAK1 (show NR2C2 ELISA Kits)
RACK1 stimulates the translation of collagen 1alpha 1, snail (show SNAI1 ELISA Kits) and cyclin E1 (show CCNE1 ELISA Kits) in hepatic stellate cells.
Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2 (show PDLIM2 ELISA Kits), MACC1 (show MACC1 ELISA Kits), NTN4, and GNB2L1.
High RACK1 expression is associated with imatinib resistance in gastrointestinal stromal tumor.
The upregulation of RACK1 can promote the proliferation and invasion of nasopharyngeal carcinoma by regulating the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/FAK (show PTK2 ELISA Kits) signal pathway.
It has been found that the adaptor protein receptor for activated PKC kinase (RACK1) formed a complex with FGFR1 and PKM2, and activated the FGFR1/PKM2 signaling. The study shows that RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells.
GNB2L1 and its O-GlcNAcylation regulated metastasis via modulating the translation of epithelial-mesenchymal transition-related proteins in the chemoresistance of gastric cancer.
Our findings suggest that RACK1 promotes proliferation and radioresistance in ESCC cells by activating the AKT (show AKT1 ELISA Kits) pathway, upregulating Bcl-2 (show BCL2 ELISA Kits) expression and downregulating protein levels of Bim (show BCL2L11 ELISA Kits). Our study fills in gaps in the field of RACK1 and radiation resistance and may provide new possibilities for improving strategies of radiotherapy in esophageal cancer.
ZNF598 (show ZNF598 ELISA Kits), RACK1, and 40S regulatory ubiquitylation plays a pivotal role in mammalian ribosome-associated quality control pathways.
beta-actin (show ACTB ELISA Kits) is a new RACK1 binding partner and that the RACK1 and beta-actin (show ACTB ELISA Kits) association participate in the cAMP-dependent regulation of BDNF (show BDNF ELISA Kits) transcription
RACK1 is required for efficient processing of the 18S rRNA 3'-end, which might be related to its role in translation initiation.
the O-GlcNAcylation on GNB2L1 reversed its inhibition on gastric tumour metastasis via promoting its degradation.
Rack1 has a dominant-negative effect on Vangl2 (show VANGL2 ELISA Kits) localization and gastrulation.
These results suggest that PKCepsilon (show PRKCE ELISA Kits) signaling in the basal airway cell may involve RACK1; however, PKCepsilon (show PRKCE ELISA Kits) regulation in ciliated cells uses RACK1-independent pathways.
RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development.
RACK1 can contribute to the recruitment of miRISC to the site of translation, and support a post-initiation mode of miRNA-mediated gene repression.
show that depletion of Caenorhabditis elegans RACK-1, which leads to short astral microtubules during prometaphase, specifically affects maintenance of cortical PAR (show AFG3L2 ELISA Kits) domains and Dynamin localization
These studies pinpoint RACK-1 as a component of a novel signaling pathway involving Rac (show AKT1 ELISA Kits) GTPases and UNC-115/abLIM (show ABLIM1 ELISA Kits).
suggest a mechanism by which RACK-1 directs the dynactin (show DCTN1 ELISA Kits)-dependent redistribution of recycling endosomes during the cell cycle
may act as a receptor for activated protein kinase C
guanine nucleotide binding protein, beta 2, related sequence 1
, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
, G-beta-like protein
, guanine nucleotide-binding protein beta subunit
, activated protein kinase C receptor
, guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 sequence 1
, guanine nucleotide binding protein related
, guanine nucleotide binding protein, beta-2, related sequence 1
, guanine nucleotide-binding protein subunit beta-2-like 1
, receptor for activated C kinase
, receptor of activated protein kinase C 1
, guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1
, guanine nucleotide binding protein, beta polypeptide 2-like 1
, protein kinase C receptor
, receptor for activated protein kinase C
, cell proliferation-inducing gene 21 protein
, guanine nucleotide-binding protein subunit beta-like protein 12.3
, human lung cancer oncogene 7 protein
, lung cancer oncogene 7
, proliferation-inducing gene 21
, protein homologous to chicken B complex protein, guanine nucleotide binding
, receptor for activated C kinase 1
, receptor of activated protein kinase C
, Guanine nucleotide-binding protein beta subunit2-like 1
, MHC B complex protein 12.3
, guanine nucleotide binding 12.3
, guanine nucleotide-binding protein beta subunit 2-like 1
, G-beta like protein