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knockdown of GPR87 led to a p53 (show TP53 ELISA Kits)-dependent signal transduction and caused apoptosis in the bladder cancer cells.
This study aimed to clarify the role of GPR87 in urothelial carcinoma of the bladder.
GPR87 promotes the growth and metastasis of CD133(+) cancer stem-like cells, and our findings may reveal new targets for HCC (show FAM126A ELISA Kits) prevention or therapy
Results suggest that the GPR87 is a LPA (show APOA ELISA Kits) receptor which evolved from a common ancestor of P2Y (show P2RY1 ELISA Kits) receptors.
G-protein coupled receptor (show ADRA1A ELISA Kits)(GPR87) stands out as a candidate for further target validation due to its marked overexpression and correlation on a mutation-based level to squamous cell carcinoma
Human GPR87 mRNA transcript was preferentially overexpressed in squamous cell carcinomas. Up-regulation of both, transcript and protein, was detected in samples of SCC (show CYP11A1 ELISA Kits) of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis).
GPR87 knockdown sensitized cancer cells to DNA damage-induced growth suppression via enhanced p53 (show TP53 ELISA Kits) stabilization and activation.
Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y (show P2RY1 ELISA Kits) receptors.
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589).
G protein-coupled receptor 87
, G-protein coupled receptor 87
, G-protein coupled receptor 87-like
, G protein-coupled receptor 95
, G-protein coupled receptor 95
, orphan GPCR 87