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Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10 (show PRLHR ELISA Kits), GPR54 (show KISS1R ELISA Kits) and GPR103 (show QRFPR ELISA Kits).
RFRP (show NPVF ELISA Kits)-3/GPR147 may play secondary, modulatory roles on the regulation of pubertal development; a restraining modulatory effect of the NPVF (show NPVF ELISA Kits) p.I71_K72 variant on the activation of the gonadotrophic axis cannot be ruled out
ovarian RFRP (show NPVF ELISA Kits)-3/GPR147 signaling could contribute to normal ovarian function
In male rats, mRNA expressions of both RFRP (show NPVF ELISA Kits) and GPR147 increases from postnatal days 12 and 16; mRNA expression of GPR147 in female rats increases from postnatal day 16, peaking at postnatal day 28 and decreasing from postnatal day 35.
GnIH homologs in the human hypothalamus and were identified and human GnIH receptor (GPR147) mRNA expression in the hypothalamus as well as in the pituitary, was characterized.
kisspeptin can act partly through neuropeptide FF receptors to modulate neuronal activity independent of GPR54 (show KISS1R ELISA Kits) in the mouse brain.
In keeping with its inhibitory role, the NPFF1R pathway seems dispensable for preserved puberty and fertility in the NPFF1 receptor null mouse.
Data showed that 33% of GnRH (show GNRH1 ELISA Kits) neurons and 9-16% of rostral periventricular kisspeptin neurons expressed Gpr147, whereas Gpr74 (show NPFF2 ELISA Kits) was not expressed in either population.
RFRP-3 may exert its effects on reproduction either directly, via Gpr147 in a subset of GnRH neurons, and/or indirectly, via upstream regulators of GnRH.
central NPFF1 and NPFF2 (show NPFF2 ELISA Kits) receptors control in an opposite manner the body temperature in mice.
The constant presence of NPFF1 receptors in the septum, the nucleus of the tractus solitarius, and the hypothalamus suggest its participation in neuroendocrine functions.
a G protein-coupled receptor that binds neuropeptide FF and BIBP3226, an anorexigenic Y1 receptor ligand and has a potential role in feeding
G protein-coupled receptor 147
, RFamide-related peptide receptor
, neuropeptide FF 1, RFamide-related peptide receptor
, neuropeptide FF receptor 1
, neuropeptide GnIHR3
, G-protein coupled receptor 147
, RFamide-related peptide receptor OT7T022
, neuropeptide FF 1
, G-protein coupled receptor NPFF1R