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polymorphisms in the NPY2R gene may be useful in identifying women at risk for osteoporosis.
The C-terminal alpha-helix of Neuropeptide Y (show NPY ELISA Kits), which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor.
Data show that the Y2-receptor high expression G allele is associated with a less efficient mode of action cascading where different task goals are activated in parallel.
The molecular mobility of the human neuropeptide Y receptor type 2 reconstituted into dimyristoylphosphatidylcholine (DMPC) membranes was investigated by means of solid-state NMR spectroscopy.
The results of this study provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing
Data indicate modest association of the age at onset (AO) with two neuropeptide Y (NPY (show NPY ELISA Kits)) promoter variations and a highly significant association with NPY (show NPY ELISA Kits) receptor NPY2R promoter single nucleotide polymorphism (SNP rs2234759).
This study reviews neuropeptide Y2 receptor modulators (mainly non-peptidic antagonists) and their structure-activity relationships.
this study concludes that common genetic variation in the proximal NPY2R promoter influences transcription factor binding so as to alter gene expression in neuroendocrine cells, and consequently cardiometabolic traits in humans.
we determined the role of the C-terminus in the anterograde transport of the human neuropeptide Y (show NPY ELISA Kits) receptor (hYR) type 2
Surface masking of the Y2 receptor could to a degree reflect restricted access of the large (34-36-residue) physiological agonists.
Findings suggest that neuropeptide Y (show NPY ELISA Kits) is expressed by distinct populations of neurons can modulate afferent and efferent projections of the central amygdala via presynaptic Y2 receptors located at inhibitory and excitatory synapses.
confirms the critical role of Y2 signalling to control neuropeptide Y (show NPY ELISA Kits) and associated pro-opiomelanocortin (show POMC ELISA Kits) expression in the arcuate nuclei
Study shows that NPY (show NPY ELISA Kits) inhibits fear learning and promotes cued extinction by reducing fear expression also via activation of presynaptic Y2 receptors on central amygdala neurons
Study shows pronounced adaptive changes in the mouse hippocampus both with regard to NPY (show NPY ELISA Kits) synthesis and NPY (show NPY ELISA Kits) receptor synthesis and binding, which may contribute to regulating neuronal seizure susceptibility after kainate
an integrated neural circuit modulates growth hormone release relative to food intake; data provide essential information to address the differential roles of Y1 and Y2 receptors in regulating the release of GH under fed and fasting states
Our results showed the altered expression of NPY (show NPY ELISA Kits), Y1R (show NPY1R ELISA Kits) and Y2R but not Y5R (show NPY5R ELISA Kits) in hippocampus and temporal lobe cortex of tremor rat brain.
Data from knockout (KO) mice suggest roles for neuropeptide Y (NPY (show NPY ELISA Kits)) and NPY2 receptors in fear acquisition/fear stimulus discrimination. Npy1r (show NPY1R ELISA Kits)/Npy2r double KO mice display excessive recall of conditioned fear/impaired fear extinction.
NPY (show NPY ELISA Kits) Y2 receptors control the level of hyperactive behavior under conditions of limited food access.
Peripheral Y2 receptor signaling is critical in the regulation of oxidative fuel selection and physical activity and protects against high-fat diet-induced obesity.
Data show that Y2R is mostly presynaptic, coexists with NPY (show NPY ELISA Kits) and NPY (show NPY ELISA Kits) Y1R (show NPY1R ELISA Kits), and suggest that Y2Rs thus have a modulatory role in mediating presynaptic neurotransmitter release.
Results suggest that rabbit and human Y1, Y2 and Y5 receptor (show NPY5R ELISA Kits) subtypes are well conserved, whereas Y4 receptors are less well conserved.
Lower mRNA levels of neuropeptide Y (show NPY ELISA Kits) receptor 1 (NPY1R (show NPY1R ELISA Kits)) and NPY5R (show NPY5R ELISA Kits) but not NPY (show NPY ELISA Kits) or NPY2R in the central nucleus of the amygdala predicted elevated anxious temperament.
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > PYY and NPY free acid.
neuropeptide Y receptor Y2
, neuropeptide Y receptor type 2
, neuropeptide Y receptor 2
, neuropeptide Y receptor type 2-like
, NPY-Y2 receptor
, Y2 receptor
, neuropeptide Y receptor Y2-like
, neuropeptide Y-Y2 receptor
, neuropeptide Y/peptide YY-Y2 receptor
, neuropeptide Y Y2 receptor
, Neuropeptide Y receptor type 2
, gastric Y2 receptor