Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
structure of a full-length class B receptor, the calcitonin receptor (show CALCR Antibodies), in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy
Data suggest that a single GlcNAc residue at CTR (show CALCR Antibodies) N130 (asparagine 130) is responsible for enhanced affinity of calcitonin (show CALCA Antibodies) for CTR (show CALCR Antibodies) ECD (show SHFM1 Antibodies); the same appears to apply for enhanced affinity of amylin (show IAPP Antibodies) for RAMP2 (show RAMP2 Antibodies)-CTR (show CALCR Antibodies) ECD (show SHFM1 Antibodies). [GlcNAc = N-acetylglucosamine; CTR (show CALCR Antibodies) = calcitonin receptor (show CALCR Antibodies); ECD (show SHFM1 Antibodies) = extracellular domain; RAMP2 (show RAMP2 Antibodies) = receptor (calcitonin) activity modifying protein 2 (show RAMP2 Antibodies)].
Males with CALCR (show CALCR Antibodies) TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India.
Calcitonin (show CALCA Antibodies) and Amylin (show IAPP Antibodies) Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR (show CALCR Antibodies) BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.
An association between fluorosis and the Alu I polymorphism in the CTR (show CALCR Antibodies) gene was observed in fluoride-exposed populations.
The C1377T polymorphism in the CTR gene is associated with bone mineral density at the lumbar spine in a postmenopausal Han Chinese population
There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis.
Data indicate a potential association between 3'UTR (show UTS2R Antibodies)+18C>T and intron 1 polymorphisms in the CALCR (show CALCR Antibodies) and the risk of kidney stone disease.
Prolonged calcitonin receptor (show CALCR Antibodies) signaling by salmon, but not human calcitonin (show CALCA Antibodies), reveals ligand bias.
High calcitonin receptor (show CALCR Antibodies) is associated with prostate cancer.
Studies show that zebrafish ctr1 is an essential gene for development.
Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 (show SLC31A2 Antibodies)
studies identify a new processing event and the key protease that cleaves the Ctr1 metal-binding ectodomain, which functions to regulate cellular Cu(+) and cisplatin acquisition
CTR1, ATP7A (show ATP7A Antibodies), and lysyl oxidase (show LOX Antibodies) were upregulated in the lung tissues and pulmonary arteries of mice with hypoxia-induced pulmonary hypertension and pulmonary arterial smooth muscle cells.
conclude that Y103 is required for the internalization of hCTR1 in response to Cu, that this occurs by a mechanism other than phosphorylation and that mutation of Y103 modulates the interaction with IRS-4 (show IRS4 Antibodies)
A key regulatory mechanism for mammalian copper transport is through Ctr2 (show SLC31A2 Antibodies)-dependent accumulation of a Ctr1 variant lacking the copper- and cisplatin-binding ecto (show TRIM33 Antibodies)-domain.
conclude that Cu acquired from CTR1 is required for signaling in pathways regulated by RTKs that play major roles in development and cance
There was little difference in rates/kinetics of uptake of copper in the Ctr1+/+ and -/- cells. Endocytosis was not involved.
basal expression of Ctr1 is regulated by HIF2alpha (show EPAS1 Antibodies); however, the induction by hypoxia is a HIF2alpha (show EPAS1 Antibodies)-independent event
Structure-functional organization of eukaryotic high-affinity copper importer CTR1 determines its ability to transport copper, silver and cisplatin
Data show apical localization of Ctr1 in intestinal epithelia and suggest that increased Ctr1 apical localization in response to dietary copper limitation may represent an adaptive response to modulate Ctr1 availability at the site of copper absorption.
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.
copper transporter 1
, high affinity copper uptake protein 1
, solute carrier family 31 member 1
, solute carrier family 31 (copper transporters), member 1
, Copper uptake transporter 1
, liver regeneration-related protein LRRGT00200
, high affinity copper uptake protein
, solute carrier family 13 (sodium/sulphate symporters), member 1