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anti-Human APOC3 Antibodies:
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Human Polyclonal APOC3 Primary Antibody for IHC (p), IP - ABIN153496
Wang, Song, Wagner, Pachuk, Subramanian: Development of a sensitive ELISA to quantify apolipoprotein CIII in nonhuman primate serum. in Journal of lipid research 2011
ApoC-III levels are significantly associated with incident coronary artery disease risk. Elevated levels of remnant lipoproteins, small dense low-density lipoprotein, and low-grade inflammation may explain this association.
The authors findings confirm an association of APOC3 with gout.
Accumulating evidence indicates that apolipoprotein C-III is a multifaceted protein which not only regulates triglyceride metabolism, but also participates in the atherosclerotic lesion formation and several other pathological processes involved in atherosclerosis.
Our results showed that APOC3 was closely associated with the inflammatory process in ECs, and that this process was characterized by the increased expression of TNF-alpha (show TNF Antibodies). Inflammatory processes further disrupted the tight junctions (TJs) between HUVECs by causing increased expression of JAM-1 (show F11R Antibodies).
Transgenic mice expressing human APOC3in the C57BL/6J background have been described. The study found that hypertriglyceridemia per se is not an independent risk factor for beta cell dysfunction in ApoC3 transgenic mice.
ApoA-1 (show APOA1 Antibodies) and ApoC-III may be used as differentiating and predictive markers for SCLC [ small cell lung cancer ].
The results of our meta-analysis point to a strong link between both APOA5 (show APOA5 Antibodies) -1131T>C and APOC3 -455T>C polymorphisms and an increased risk of coronary heart disease .
HDL (show HSD11B1 Antibodies)-apoCIII has a significant and positive association with coronary heart disease .
Low levels of APOA1 (show APOA1 Antibodies), APOC3, and APOA4 (show APOA4 Antibodies) are associated with risk of Alzheimer disease.
APOA5 (show APOA5 Antibodies) -1131 T > C and APOC3 -455 T > C SNPs may play potent roles in the development and progression of coronary heart disease. (Meta-analysis)
Severe hypertriglyceridaemia resulting from ApoCIII overexpression promotes restenosis and atherosclerosis
Under conditions of islet insulin (show INS Antibodies) resistance, locally produced apoCIII is an important diabetogenic factor involved in impairment of beta-cell function.
decreased ApoAI synthesis might be accounted for the lower plasma HDL (show HSD11B1 Antibodies) level in ApoCIII transgenic mice
ApoCIII hyperactivates beta cell CaV1 (show CAV1 Antibodies) channels through SR-BI (show SCARB1 Antibodies)/beta1 integrin-dependent coactivation of PKA and Src (show SRC Antibodies).
Increased plasma APOC3 concentrations predispose mice to diet-induced nonalcoholic fatty liver and hepatic insulin (show INS Antibodies) resistance.
Glucose induces apoCIII transcription, which may represent a mechanism linking hyperglycemia, hypertriglyceridemia, and cardiovascular disease in type 2 diabetes.
PGC-1beta (show PPARGC1B Antibodies) regulates plasma triglyceride metabolism through stimulating apolipoprotein C3 (APOC3) expression and elevating APOC3 levels in circulation
The apoC-III metabolism may contribute to dyslipidemia in CKD, and this requires further investigation.
ApoB (show APOB Antibodies) lipoproteins that contain apoCIII increase THP-1 (show GLI2 Antibodies) cell adhesion to ECs via PKCalpha (show PKCa Antibodies) and RhoA (show RHOA Antibodies)-mediated beta1-integrin activation.
oxidized fatty acids may act through an APOA5 (show APOA5 Antibodies)/APOClll mechanism that contributes to lowering of TG levels other than PPAR (show PPARA Antibodies)* induction
gene polymorphisms in APOA5 (show APOA5 Antibodies) and APOC3 are associated with meat quality traits in Kele pigs
changes in apolipoprotein A-I (show APOA1 Antibodies) and apo (show C9orf3 Antibodies) C-III mRNA were reflected in their corresponding plasma levels
apoC-I (show APOC1 Antibodies) and apoC-III inhibit lipolysis by displacing LPL (show LPL Antibodies) from lipid emulsion particles. We also propose a role for these apolipoproteins in the irreversible inactivation of LPL (show LPL Antibodies) by factors such as angptl4 (show ANGPTL4 Antibodies).
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase\; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
, apolipoprotein C3
, apolipoprotein C-3
, apolipoprotein CIII