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in FoxA2 (show FOXA2 Proteins)-FoxA3 double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
FoxA3 and goosecoid (show GSC Proteins) cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a (show WNT8A Proteins).
Our study identified novel FOXA3 variants and mutations, assessed the adipogenic capacity of two novel missense alterations in vitro and demonstrated for the first time the associations between FOXA3 SNP rs28666870 with metabolic phenotypes in humans.
Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity in asthma and chronic obstructive pulmonary disease.
In obese subjects, FOXA3 is differentially expressed in visceral and su (show CEBPB Proteins)bcutaneous adipose depots.
low caloric intake decreases the production of intracellular reactive oxygen species and suppresses endothelial cells senescence through promoting HNF3gamma binging to NOX4 (show NOX4 Proteins) promoter region and inhibiting NOX4 (show NOX4 Proteins) gene expression induced by up-regulated HNF3gamma
analysis of the binding pattern of FOXA1 (show FOXA1 Proteins) and FOXA3 and their relation to H3K4me3 in HepG2 cells
the HNF-3 (show FOXM1 Proteins) site in the fibrinogen beta promoter is important for IL6 (show IL6 Proteins)-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism
FOXA3 is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra (show PDGFRA Proteins) transcription in Leydig cells.
These findings reveal an obligatory coregulatory role of Foxa3 in the regulation of ER-alpha (show ESR1 Proteins) expression and of the Foxa3/ER-alpha (show ESR1 Proteins) cascade, at least in part, in the pathogenesis of androgen deficiency caused by type 2 diabetes mellitus.
These results demonstrated the crucial role of Hnf1b (show HNF1B Proteins) and Foxa3 in hepatogenesis in vitro and provided a valuable tool for the efficient differentiation of HLCs (show HLCS Proteins) from ES cells.
studies provide the first demonstration, to our knowledge, that Foxa3 is a direct target of GC action in adipose tissues and point to a role of Foxa3 as a mediator of the side effects induced in fat tissues by chronic treatment with synthetic steroids
transcription factor Foxa3 was a strong promoter of liver regeneration.
during aging, Foxa3 is up-regulated in brown and inguinal white fat depots, and midage Foxa3-null mice have increased white fat browning and thermogenic capacity, decreased adipose tissue expansion, improved insulin (show INS Proteins) sensitivity, and increased longevity
Foxa3 promotes adipocyte differentiation by cooperating with C/EBP beta (show CEBPB Proteins) and - delta to transcriptionally induce PPAR gamma (show PPARG Proteins) expression.
these results suggested that oxidative stress inhibited Akt (show AKT1 Proteins) signaling and facilitated the FOXO (show FOXO3 Proteins)-3a/FBXO-dependent BK-beta(1) degradation in diabetic vessels.
Intraovarian excess androgen in polycystic ovary syndrome may result in excess (show RCC1 Proteins) follicles by inducind Foxo (show FOXO3 Proteins) 3a translocation.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved.
forkhead box A3
, fork head domain protein 2
, hepatocyte nuclear factor 3-gamma
, fork head-related protein FKH H3
, forkhead box protein A3
, hepatocyte nuclear factor 3, gamma
, transcription factor 3G
, foxhead box A3
, hepatocyte nuclear factor 3 gamma
, hepatocyte nuclear factor 3 gamma (winged helix transcription factor)