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Rat (Rattus) NOX4 ELISA Kit for Sandwich ELISA - ABIN431602
El-Naga: Apocynin protects against ethanol-induced gastric ulcer in rats by attenuating the upregulation of NADPH oxidases 1 and 4. in Chemico-biological interactions 2015
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Human NOX4 ELISA Kit for Sandwich ELISA - ABIN417447
Vital, Castro, Ittmann: Oxidative stress promotes benign prostatic hyperplasia. in The Prostate 2016
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This study also showed that UCH-L1 (show UCHL1 ELISA Kits) promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS (show ROS1 ELISA Kits) by deubiquitination of NOX4, suggesting that UCH-L1 (show UCHL1 ELISA Kits) plays a key role in angiogenesis of HUVECS by regulating ROS (show ROS1 ELISA Kits) levels by deubiquitination of NOX4.
The results reveal that NOX4 promotes glycolysis, contributing to non-small cell lung cancer cells growth, and supports glutaminolysis for oxidative resistance.
Metformin attenuates idiopathic lung fibrosis development via suppression of myofibroblast NOX4 expression.
Letter: airway smooth muscle cell NOX4 expression is increased in vivo and in vitro in COPD (show ARCN1 ELISA Kits).
TIS21 (show BTG2 ELISA Kits) attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS (show ROS1 ELISA Kits)-ABI2-DRF (show MPO ELISA Kits) signal cascade
These results are consistent with the hypothesis that antioxidants or NOX1 (show NOX1 ELISA Kits)/4 inhibition may be useful in blocking profibrotic effects of TGFbeta (show TGFB1 ELISA Kits) on dermal and gingival fibroblasts and warrant consideration for further development as potential antifibrotic agents
These data suggested that t-BHP induced both apoptosis and necroptosis in endothelial cells which was mediated by ROS (show ROS1 ELISA Kits) and p38MAPK (show MAPK14 ELISA Kits). ROS (show ROS1 ELISA Kits) derived from NADPH oxidase (show NOX1 ELISA Kits) and mitochondria contributed to t-BHPL and t-BHPH-induced apoptosis and necroptosis, respectively
Brd4 (show BRD4 ELISA Kits) inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-beta (show TGFB1 ELISA Kits)-mediated Nox4 expression.
We demonstrated that rapid deletion of p22phox (show CYBA ELISA Kits) is possible and that the activity of Nox1 (show NOX1 ELISA Kits) and Nox4 but not Nox5 (show NOX5 ELISA Kits) exclusively depends on p22phox (show CYBA ELISA Kits).
These processes are mediated upstream by the reactive oxygen species (ROS (show ROS1 ELISA Kits))-producing enzyme Nox4.
NOX4 actively regulates smooth muscle cells (SMC (show DYM ELISA Kits)) pathophysiological responses in diabetic Apoe (show APOE ELISA Kits)(-/-) mice and in primary mouse SMCs through the activities of PDGF (show PDGFA ELISA Kits) and NOX1 (show NOX1 ELISA Kits).
we used the Ang II (show AGT ELISA Kits) infused hph-1 (show EGLN2 ELISA Kits) mice to examine the roles of NOX isoforms in the development of AAA (show AAAS ELISA Kits). We generated double mutants of hph-1 (show EGLN2 ELISA Kits)-NOX1 (show NOX1 ELISA Kits), hph-1 (show EGLN2 ELISA Kits)-NOX2 (show CYBB ELISA Kits), hph-1 (show EGLN2 ELISA Kits)-p47phox, and hph-1 (show EGLN2 ELISA Kits)-NOX4
The major reactive oxygen species (ROS (show ROS1 ELISA Kits)) source in brain, NADPH oxidase (show NOX1 ELISA Kits) subunit 4 increased in hypoxia but not in hyperoxia, whereas neither affected nuclear factor (erythroid-derived 2)-like 2 (show NFE2L2 ELISA Kits), a transcription factor that regulates the expression of antioxidant proteins
Nox4 has no influence on lifespan of healthy mice.
MFA has a protective effect on alcohol-induced liver injury, which may be related to its antioxidant,anti-inflammatory,lipid-eliminating properties and its ability to regulate the NOX4/ROS (show ROS1 ELISA Kits)-MAPK (show MAPK1 ELISA Kits) signalling pathway.
Nox2 (show CYBB ELISA Kits)- and Nox4-derived reactive oxygen species contribute to stem cell pluripotency maintenance and self-renewal.
FYN (show FYN ELISA Kits) is activated by oxidative stress and serves as a negative feedback regulator of NOX4 in cardiomyocytes during cardiac remodeling
NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 (show EDN1 ELISA Kits) production.
Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.
MRTF down-regulation/inhibition suppresses TGFbeta (show TGFB1 ELISA Kits)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.
Nox4 NADPH oxidase (show NOX1 ELISA Kits) mediates oxidative stress and apoptosis caused by TNF-alpha (show TNF ELISA Kits) in cerebral vascular endothelial cells.
Nox4 NADPH oxidase (show NOX1 ELISA Kits)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (show HMOX2 ELISA Kits).
proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (show NOX1 ELISA Kits) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (show P4HB ELISA Kits) mRNA expression
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
, kidney superoxide-producing NADPH oxidase
, renal NAD(P)H-oxidase
, superoxide-generating NADPH oxidase 4
, NADPH oxidase 4
, predicted NADPH oxidase-4