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anti-Human TJP1 Antibodies:
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Human Monoclonal TJP1 Primary Antibody for IF, WB - ABIN968282
Ebnet, Schulz, Meyer Zu Brickwedde, Pendl, Vestweber: Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. in The Journal of biological chemistry 2000
Show all 4 Pubmed References
Human Monoclonal TJP1 Primary Antibody for IF, WB - ABIN968283
Hirase, Kawashima, Wong, Ueyama, Rikitake, Tsukita, Yokoyama, Staddon: Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms. in The Journal of biological chemistry 2001
Show all 4 Pubmed References
Human Polyclonal TJP1 Primary Antibody for IF (cc), IF (p) - ABIN675024
Gu, Xue, Wei, Zhang, Li: Calcium-activated potassium channel activator down-regulated the expression of tight junction protein in brain tumor model in rats. in Neuroscience letters 2011
Show all 4 Pubmed References
Human Polyclonal TJP1 Primary Antibody for ICC, IF - ABIN4359733
Gangl, Reininger, Bernhard, Campana, Pree, Reisinger, Kneidinger, Kundi, Dolznig, Thurnher, Valent, Chen, Vrtala, Spitzauer, Valenta, Niederberger: Cigarette smoke facilitates allergen penetration across respiratory epithelium. in Allergy 2009
Show all 2 Pubmed References
Human Polyclonal TJP1 Primary Antibody for IF - ABIN2192206
Balda, Anderson: Two classes of tight junctions are revealed by ZO-1 isoforms. in The American journal of physiology 1993
Human Polyclonal TJP1 Primary Antibody for ELISA, WB - ABIN4359730
Zhong, Deane, Ali, Parisi, Shapovalov, OBanion, Stojanovic, Sagare, Boillee, Cleveland, Zlokovic: ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. in Nature neuroscience 2008
Human Polyclonal TJP1 Primary Antibody for ICC, IF - ABIN4359735
McIntyre, Alev, Mechael, Salci, Lee, Fiebig-Comyn, Guezguez, Wu, Sheng, Bhatia: Expansive generation of functional airway epithelium from human embryonic stem cells. in Stem cells translational medicine 2014
Aberrant expression of the tight junction molecules claudin-1 (show CLDN7 Antibodies) and zonula occludens-1 mediates cell growth and invasion in oral squamous cell carcinoma cells.
ZO-1-occludin (show OCLN Antibodies) interactions regulate multiple phases of epithelial polarization by providing cell-intrinsic signals that are required for single lumen formation.
It is postulated that ZO-1, when not phosphorylated by PKC (show PRRT2 Antibodies), keeps Octn2 (show SLC22A5 Antibodies) in an active state, while elimination of this binding in DeltaPDZ mutant or after ZO-1 phosphorylation leads to diminution of Octn2 (show SLC22A5 Antibodies) activity.
Results uncovered ZO-1 as part of a signaling node activated by VEGF (show VEGFA Antibodies), but not Ang-1 (show ANGPT1 Antibodies), that specifically modulates endothelial cells proliferation during angiogenesis.
Data suggest that long noncoding RNA PlncRNA1 and microRNA miR (show MLXIP Antibodies)-34c bound together to regulate the expressions of MAZ (show MAZ Antibodies), ZO-1 and occludin (show OCLN Antibodies).
STAT3 activation downregulates the ZO-1 and occludin levels and increases the endothelial permeability through the induction of VEGF production in retinal endothelial cells.
Data show that tight junction protein 1 (TJP1) suppressed expression of the catalytically proteasome subunits LMP7 (show PSMB8 Antibodies) and LMP2 (show PSMB9 Antibodies), decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR (show EGFR Antibodies)/JAK1 (show JAK1 Antibodies)/STAT3 (show STAT3 Antibodies) signaling.
ZO-1 highly expresses in cell-cell junctions and is related to odontoblast differentiation, which may contribute to dental pulp repair or even the formation of an odontoblast layer.
this study shows that the expression and the immunoreactivity of ZO-1 is decreased in the nasal epithelium of patients with allergic rhinitis
The frequency of alleles and genotypes of rs2291166 gene polymorphism TJP1 was determined in the Mexico Mestizos population. The ancestral allele was the most prevalent. The conformational effect of this amino acid change was performed in silico.
Cx43 (show GJA1 Antibodies) tethers the F-actin cytoskeleton through a ZO-1 linker and supports cell spreading and exploration during locomotion in cerebral endothelial cells.
Expression of Podocalyxin (show PODXL Antibodies), which positively regulates the formation of microvilli and the apical membrane, is repressed in embryoid bodies lacking both ZO-1 and ZO-2 (show TJP2 Antibodies) and this correlates with an aberrant submembranous localization of Ezrin (show EZR Antibodies).
Zonula occludens-1, occludin (show OCLN Antibodies) and E-cadherin (show CDH1 Antibodies) expression and organization in salivary glands
Tjp1 expression was decreased in glomerular diseases in human and animal models, our results indicate that the suppression of Tjp1 could directly aggravate glomerular disorders, highlights Tjp1 as a potential therapeutic target.
Arecoline increases the production of TNF-alpha (show TNF Antibodies) and induces protein redistribution of ZO-1.
Vcl (show VCL Antibodies) plays a crucial role in stabilizing gap junctions and myocyte integrity through direct interactions with ZO-1 and stabilization of CX43 (show GJA1 Antibodies).
Activation of RhoA (show RHOA Antibodies)/ROCK1 (show ROCK1 Antibodies) by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin (show OCLN Antibodies)/ZO-1, which can be corrected by simvastatin.
Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C epsilon (show PRKCE Antibodies)-mediated zona occludens-1 phosphorylation at threonine 770/772.
The JAM-A (show F11R Antibodies) and ZO-1 genes were highly expressed in all the tested tissues.
cyclic strain modulates both the expression and phosphorylation state of occludin (show OCLN Antibodies) and ZO-1 in vascular endothelial cells, with putative consequences for endothelial tight junction assembly and barrier integrity
ZO-1 and occludin (show OCLN Antibodies) are expressed in oocytes and preimplantation embryos, and that ZO-1alpha+ is transcribed by zygotic gene activation and translated from early blastocysts with prominent increase of occludin (show OCLN Antibodies) at the blastocyst stage.
This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.
tight junction protein ZO-1
, zona occludens 1
, zona occludens protein 1
, zonula occludens 1 protein
, zonula occludens protein 1
, tight junction protein 1 (zona occludens 1)
, zonula occludens 1