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Browse our anti-APP (APP) Antibodies

Full name:
anti-Amyloid beta (A4) Precursor Protein Antibodies (APP)
On www.antibodies-online.com are 854 Amyloid beta (A4) Precursor Protein (APP) Antibodies from 40 different suppliers available. Additionally we are shipping APP Kits (92) and APP Proteins (47) and many more products for this protein. A total of 1028 APP products are currently listed.
Synonyms:
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740

Most Popular Reactivities for anti-APP (APP) Antibodies

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anti-Human APP Antibodies:

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Top referenced anti-APP Antibodies

  1. Human Polyclonal APP Primary Antibody for EIA, WB - ABIN4620398 : Borroni, Colciaghi, Caltagirone, Rozzini, Broglio, Cattabeni, Di Luca, Padovani: Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study. in Archives of neurology 2003 (PubMed)
    Show all 5 references for ABIN4620398

  2. Human Polyclonal APP Primary Antibody for WB - ABIN389515 : Lleó, Berezovska, Ramdya, Fukumoto, Raju, Shah, Hyman: Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN389515

  3. Human Polyclonal APP Primary Antibody for EIA, WB - ABIN358841 : Zhou, Su, Li, Liu, Ryder, Wu, Gonzalez-DeWhitt, Gelfanova, Hale, May, Paul, Ni: Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. in Science (New York, N.Y.) 2003 (PubMed)
    Show all 5 references for ABIN358841

  4. Human Polyclonal APP Primary Antibody for IF, WB - ABIN197432 : Eng, Lund, Campenot: Synthesis of beta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 (PubMed)
    Show all 4 references for ABIN197432

  5. Human Monoclonal APP Primary Antibody for WB - ABIN1449275 : Gylys, Fein, Yang, Wiley, Miller, Cole: Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. in The American journal of pathology 2004 (PubMed)
    Show all 3 references for ABIN1449275

  6. Human Polyclonal APP Primary Antibody for WB - ABIN652995 : Chen, Fernandez: Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein. in Biochemical and biophysical research communications 2005 (PubMed)
    Show all 3 references for ABIN652995

  7. Human Polyclonal APP Primary Antibody for IF, IHC (p) - ABIN657612 : Singh, Park, Bae, Yun, Bae, Park, Kim: MEGF10 functions as a receptor for the uptake of amyloid-β. in FEBS letters 2010 (PubMed)
    Show all 2 references for ABIN657612

  8. Chicken Polyclonal APP Primary Antibody for WB - ABIN2778227 : Locascio, Fukumoto, Yap, Bottiglieri, Growdon, Hyman, Irizarry: Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. in Archives of neurology 2008 (PubMed)

More Antibodies against APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  2. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  3. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  4. APPL is the first example of a modulator of the Wnt (show WNT4 Antibodies)-PCP (show PRCP Antibodies) pathway specifically required for axon outgrowth.

  5. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 Antibodies) pathway through a mechanism mediated by PntP2 (show ETS2 Antibodies).

  6. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  7. Disruption of amyloid protein (show IAPP Antibodies) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  8. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 Antibodies)) reduces amyloid-beta production by altering Nicastrin (show NCSTN Antibodies) maturation and intracellular localization.

  9. accumulation of Ass42 plaques induces JNK (show MAPK8 Antibodies) signaling in neurons and induction of JNK (show MAPK8 Antibodies) contributes to Ass42 mediated cell death

  10. in adult flies, APPL is not required for learning but is specifically involved in long-term memory, a long lasting memory whose formation requires de novo protein synthesis and is thought to require synaptic structural plasticity.

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Study of an MPTP (show PTPN2 Antibodies)-induced cell model of Parkinson's disease, discovered the interactions between hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-144-3p and APP. MiR (show MLXIP Antibodies)-144-3p was found to be down-regulated, along with its target gene APP that participates in regulating MPTP (show PTPN2 Antibodies)-induced mitochondrial dysfunction.

  2. Data show that valproic acid (VPA) treatment enhanced gender-dependent learning and memory impairment in the human amyloid beta precursor protein/presenilin 1 (show PSEN1 Antibodies) (APP/PS1 (show PSEN1 Antibodies)) double transgenic mice.

  3. IGF-I (show IGF1 Antibodies) showed a significant negative correlation with age (beta = -0.357, P = 0.002) and a positive correlation with Abeta42/Abeta40 ratio (beta = 0.318, P = 0.007).

  4. These data suggest that excess O-glycosylation on APP by GalNAc-T6 (show GALNT6 Antibodies) inhibits Abeta production.

  5. KFERQ motif is important for normal processing and degradation of APP

  6. Asian patients with APP mutations presented less frequently with aphasia. Thus, clinical features could be modified by underlying mutations, and Asian familial Alzheimer's disease patients may have different clinical features when compared with whites. [review]

  7. ACAT1 (show ACAT1 Antibodies) has a role in regulating the dynamics of free cholesterols in plasma membrane which leads to the APP-alpha-processing alteration

  8. Data showed that in both PC12 cells and primary neurons, human Abeta1-42 oligomers triggered endoplasmic reticulum stress, leading to insulin (show INS Antibodies) signaling impairment mediated by JNK (show MAPK8 Antibodies)-dependent IRS-1 (show IRS1 Antibodies) serine phosphorylation, ultimately resulting in Tau hyperphosphorylation, which is correlated with the formation of neurofibrillary tangles.

  9. Study with MDR1A (show ABCB4 Antibodies) knockout mice were crossed with Tg2576 APP transgenic mice indicate that Abeta accumulates to a greater degree in brains of mice lacking MDR1A (show ABCB4 Antibodies)

  10. Results indicate that persistent rab5 (show RAB5A Antibodies) overactivation through beta-cleaved carboxy-terminal fragment of APP-APPL1 (show APPL1 Antibodies) interactions constitutes a novel APP-dependent pathogenic pathway in Alzheimer's disease

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Antibodies)- and CD47 (show CD47 Antibodies)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE Antibodies) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Results indicate that isomerization of Asp7 and phosphorylation of Ser8 of the amyloid beta peptide (Abeta) backbone have a significant impact on the profiles of brain Abeta binding proteins.

  2. Cadmium induces cell death on cholinergic neurons through blockade of M1 receptor, overexpression of AChE-S and GSK-3beta (show GSK3b Antibodies), down-regulation of AChE-R and increase in Abeta and total and phosphorylated tau protein levels.

  3. plasma Abeta(1-42) concentration increases with age, while the concentration of Abeta(1-42) in the cerebrospinal fluid (CSF (show CSF2 Antibodies)) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice.

  4. A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve (show PIKFYVE Antibodies) activity.

  5. APP, tau, and synaptophysin (show SYP Antibodies) were elevated in in the medial preoptic area in both the B6D2F1 and BXB1 maters relative to the B6D2F1 and BXB1 non-maters,suggesting a potential genetic mechanism for inheritance of steroid-independent male sexual behavior.

  6. folic acid deficiency can enhance Abeta accumulation in APP/PS1 (show PSEN1 Antibodies) mice brain and decrease amyloid-associated miRNAs expression

  7. These data support the notion that APP and APLP2 (show APLP2 Antibodies) facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery.

  8. EphB2 (show EPHB2 Antibodies) prevents amyloid-beta-induced depletion of cell surface GluN1 (show GRIN1 Antibodies) requiring the PDZ (show INADL Antibodies)-binding motif of EphB2 (show EPHB2 Antibodies).

  9. Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.

  10. the absence of Mt3 reduces Abeta uptake in astrocytes through an abnormality in actin polymerization.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 Antibodies)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP Antibodies) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 Antibodies) and Aplp2 (show APLP2 Antibodies) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 Antibodies)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 Antibodies) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 Antibodies) signaling

APP Antigen Profile

Antigen Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl) antibody
  • amyloid beta (A4) precursor protein (APP) antibody
  • amyloid beta (A4) precursor protein (app) antibody
  • amyloid beta (A4) precursor protein (App) antibody
  • amyloid beta (A4) precursor protein a (appa) antibody
  • beta amyloid protein precursor (LOC100009546) antibody
  • AAA antibody
  • ABETA antibody
  • Abpp antibody
  • AD1 antibody
  • Adap antibody
  • Ag antibody
  • app antibody
  • APP-like antibody
  • APPI antibody
  • appl antibody
  • BcDNA:GH04413 antibody
  • betaApp antibody
  • CG7727 antibody
  • CTFgamma antibody
  • Cvap antibody
  • Dmel\\CG7727 antibody
  • E030013M08Rik antibody
  • EG:65F1.5 antibody
  • PN-II antibody
  • PN2 antibody
  • wu:fj34d10 antibody
  • wu:fk65e12 antibody
  • zgc:85740 antibody

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

GENE ID SPECIES
31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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