Browse our anti-APP (APP) Antibodies

Full name:
anti-Amyloid beta (A4) Precursor Protein Antibodies (APP)
On www.antibodies-online.com are 860 Amyloid beta (A4) Precursor Protein (APP) Antibodies from 43 different suppliers available. Additionally we are shipping APP Kits (106) and APP Proteins (46) and many more products for this protein. A total of 1047 APP products are currently listed.
Synonyms:
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740

Most Popular Reactivities for anti-APP (APP) Antibodies

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Top referenced anti-APP Antibodies

  1. Human Polyclonal APP Primary Antibody for EIA, WB - ABIN358081 : Borroni, Colciaghi, Caltagirone, Rozzini, Broglio, Cattabeni, Di Luca, Padovani: Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study. in Archives of neurology 2003 (PubMed)
    Show all 5 references for 358081

  2. Human Polyclonal APP Primary Antibody for WB - ABIN389515 : Lleó, Berezovska, Ramdya, Fukumoto, Raju, Shah, Hyman: Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for 389515

  3. Human Polyclonal APP Primary Antibody for EIA, WB - ABIN358841 : Zhou, Su, Li, Liu, Ryder, Wu, Gonzalez-DeWhitt, Gelfanova, Hale, May, Paul, Ni: Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho. in Science (New York, N.Y.) 2003 (PubMed)
    Show all 5 references for 358841

  4. Human Polyclonal APP Primary Antibody for IF, WB - ABIN197432 : Eng, Lund, Campenot: Synthesis of beta-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 (PubMed)
    Show all 4 references for 197432

  5. Human Polyclonal APP Primary Antibody for WB - ABIN652995 : Chen, Fernandez: Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein. in Biochemical and biophysical research communications 2005 (PubMed)
    Show all 3 references for 652995

  6. Human Monoclonal APP Primary Antibody for WB - ABIN1449275 : Gylys, Fein, Yang, Wiley, Miller, Cole: Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence. in The American journal of pathology 2004 (PubMed)
    Show all 3 references for 1449275

  7. Human Polyclonal APP Primary Antibody for IF, IHC (p) - ABIN657612 : Singh, Park, Bae, Yun, Bae, Park, Kim: MEGF10 functions as a receptor for the uptake of amyloid-β. in FEBS letters 2010 (PubMed)
    Show all 2 references for 657612

  8. Cow (Bovine) Polyclonal APP Primary Antibody for WB - ABIN2777738 : Locascio, Fukumoto, Yap, Bottiglieri, Growdon, Hyman, Irizarry: Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. in Archives of neurology 2008 (PubMed)

More Antibodies against APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (show GRIN2A Antibodies) recycling.

  2. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  3. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  4. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  5. APPL is the first example of a modulator of the Wnt (show WNT4 Antibodies)-PCP (show PRCP Antibodies) pathway specifically required for axon outgrowth.

  6. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 Antibodies) pathway through a mechanism mediated by PntP2 (show ETS2 Antibodies).

  7. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  8. Disruption of amyloid protein (show IAPP Antibodies) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  9. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 Antibodies)) reduces amyloid-beta production by altering Nicastrin (show NCSTN Antibodies) maturation and intracellular localization.

  10. accumulation of Ass42 plaques induces JNK (show MAPK8 Antibodies) signaling in neurons and induction of JNK (show MAPK8 Antibodies) contributes to Ass42 mediated cell death

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. UBQLN4 (show UBQLN4 Antibodies), APP, CTNNB1 (show CTNNB1 Antibodies), SHBG (show SHBG Antibodies), and COL1A1 (show COL1A1 Antibodies) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition

  2. Fe65 (show APBB1 Antibodies) is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-beta precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 (show APBB1 Antibodies) constructs expressed in human neuroblastoma (show ARHGEF16 Antibodies) cells. Our results indicate that PTB2 (show PTBP1 Antibodies) rather than the WW domain (show DRP2 Antibodies) is important for the nuclear localization of Fe65 (show APBB1 Antibodies).

  3. bis (show BAG3 Antibodies)(sulfosuccinimidyl) suberate (BS3) was used to cross-link Abeta1-42 oligomers prior to electrophoresis. When compared to a previously reported Abeta cross-linking agent, glutaraldehyde, it was quite apparent that BS3 is more suitable for detecting intra-membrane Abeta oligomers and extra-membrane Abeta oligomers states.

  4. This is the first report to show decreased Amyloid beta levels in plasma in Amyloid beta Precursor Protein A673T carriers and thus provides evidence that lower Abeta levels throughout life may be protective against Alzheimer Disease.

  5. APP + PS1 (show PSEN1 Antibodies) double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP + PS1 (show PSEN1 Antibodies) rats showed brain pathology as well as reduced memory retention compared to the APP and the ...

  6. common in cognitively normal older adults. However, evidence of pathological effects on episodic memory has largely been limited to beta-amyloid (Abeta). Because Abeta and tau often cooccur in older adults, previous research offers an incomplete understanding of the relationship between pathology and episodic memory.

  7. APP overexpression is associated with Down syndrome.

  8. SEPT8 (show SEPT8 Antibodies) modulates beta-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1 (show BACE Antibodies).

  9. Using purified PSEN1 (show PSEN1 Antibodies)/Aph1A (show APH1A Antibodies) gamma-secretase and the APPC99-3XFLAG substrate, authors show that substrate shortening progressively destabilizes the consecutive enzyme-substrate complexes that characterize the sequential gamma-secretase processing of APP; present a unifying model for how PSEN (show PSEN1 Antibodies) or APP mutations enhance amyloidogenic Abeta production, suggests that environmental factors may increase Alzheimer's Disease risk.

  10. Data suggest that, at neutral pH, amyloid fibril formation is destabilized by substitution of any histidine residue to alanine in amyloid beta-protein (1 (show DLX4 Antibodies)-40) by a factor of 4-12 compared to wild-type; however, none of His-Ala variants impact the stability of amyloid fibrils at low pH.

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Antibodies)- and CD47 (show CD47 Antibodies)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE Antibodies) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. ABETA 25-35 downregulated miR (show MLXIP Antibodies)-137 and upregulated TNFAIP1 (show TNFAIP1 Antibodies) in cortical neurons and N2a cells.

  2. These results indicate that platelet APP limits venous thromboembolism through a negative regulation of both fibrin formation and neutrophil function.

  3. These findings highlight for the first time that APP-dependent glial cell line-derived neurotropic factor expression drives the process of neuromuscular junction formation, providing new insights into the link between APP gene regulatory network and physiologic functions.

  4. TREM2 (show TREM2 Antibodies) protects from Alzheimer's disease by enabling microglia to surround and alter Abeta plaque structure, thereby limiting neuritic damage.

  5. To conclude, our data corroborate a major role of APP for structural plasticity and adaptive remodeling of cortical synapses in the adult brain. They also indicate that lack of APP holoprotein leads to impaired D-serine homeostasis, which is associated with dysfunctional synaptic plasticity.

  6. Pretreatment with a P-glycoprotein inhibitor, which blocks blood-brain barrier transport of Abeta, resulted in significant prolongation of Abeta40 half-life, but only in the latter phase of Abeta clearance from the interstitial fluid.

  7. in Alzheimer's disease (AD) brains, elevated DAPK1 (show DAPK1 Antibodies) levels showed co-relation with the increase of APP phosphorylation. Combined together, these results suggest that DAPK1 (show DAPK1 Antibodies) promotes the phosphorylation and amyloidogenic processing of APP, and that may serve a potential therapeutic target for AD.

  8. The Amyloid Precursor Protein contributes to calcium homeostasis in situations of metabolic stress. This finding may shed light on the physiological function of APP and may be important for understanding mechanisms of neurodegenerative diseases.

  9. The levels of MTERF4 protein were significantly increased in the hippocampus of APP/PS1 (show PSEN1 Antibodies) mice, an animal model of Alzheimer's disease.

  10. The results indicate that Nrx2alpha and NL1 (show MMEL1 Antibodies) are targets of Abeta oligomers and that prevention of this interaction reduces the deleterious impact of Abeta oligomers on synapses and cognition.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 Antibodies)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP Antibodies) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 Antibodies) and Aplp2 (show APLP2 Antibodies) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 Antibodies)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 Antibodies) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 Antibodies) signaling

APP Antigen Profile

Antigen Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl) antibody
  • amyloid beta (A4) precursor protein (APP) antibody
  • amyloid beta (A4) precursor protein (app) antibody
  • amyloid beta (A4) precursor protein (App) antibody
  • amyloid beta (A4) precursor protein a (appa) antibody
  • beta amyloid protein precursor (LOC100009546) antibody
  • AAA antibody
  • ABETA antibody
  • Abpp antibody
  • AD1 antibody
  • Adap antibody
  • Ag antibody
  • app antibody
  • APP-like antibody
  • APPI antibody
  • appl antibody
  • BcDNA:GH04413 antibody
  • betaApp antibody
  • CG7727 antibody
  • CTFgamma antibody
  • Cvap antibody
  • Dmel\\CG7727 antibody
  • E030013M08Rik antibody
  • EG:65F1.5 antibody
  • PN-II antibody
  • PN2 antibody
  • wu:fj34d10 antibody
  • wu:fk65e12 antibody
  • zgc:85740 antibody

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

GENE ID SPECIES
31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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