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Browse our APP (APP) ELISA Kits

Full name:
Amyloid beta (A4) Precursor Protein ELISA Kits (APP)
On www.antibodies-online.com are 107 Amyloid beta (A4) Precursor Protein (APP) ELISA Kits from 15 different suppliers available. Additionally we are shipping APP Antibodies (848) and APP Proteins (47) and many more products for this protein. A total of 1074 APP products are currently listed.
Synonyms:
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740

Top referenced APP ELISA Kits

  1. Human APP ELISA Kit for Sandwich ELISA - ABIN414520 : Shi, Wu, Xu, Zou: Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. in Neurochemistry international 2011 (PubMed)
    Show all 2 references for ABIN414520

  2. Rat (Rattus) APP ELISA Kit for Sandwich ELISA - ABIN810848 : Tian, Guo, Yue, Lv, Ye, Wang, Chen, Wu, Xu, Liu: Intranasal administration of nerve growth factor ameliorate ?-amyloid deposition after traumatic brain injury in rats. in Brain research 2012 (PubMed)

More ELISA Kits for APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  2. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  3. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  4. APPL is the first example of a modulator of the Wnt (show WNT4 ELISA Kits)-PCP (show PRCP ELISA Kits) pathway specifically required for axon outgrowth.

  5. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 ELISA Kits) pathway through a mechanism mediated by PntP2 (show ETS2 ELISA Kits).

  6. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  7. Disruption of amyloid protein (show IAPP ELISA Kits) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  8. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 ELISA Kits)) reduces amyloid-beta production by altering Nicastrin (show NCSTN ELISA Kits) maturation and intracellular localization.

  9. accumulation of Ass42 plaques induces JNK (show MAPK8 ELISA Kits) signaling in neurons and induction of JNK (show MAPK8 ELISA Kits) contributes to Ass42 mediated cell death

  10. in adult flies, APPL is not required for learning but is specifically involved in long-term memory, a long lasting memory whose formation requires de novo protein synthesis and is thought to require synaptic structural plasticity.

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Pharmacophore-based screening targeted at upregulated FN1 (show FN1 ELISA Kits), MMP-9 (show MMP9 ELISA Kits), APP reveals therapeutic compounds for nasopharyngeal carcinoma.

  2. These findings identify Syt1 (show SYT1 ELISA Kits) as a novel Ca(2 (show CA2 ELISA Kits)+)-sensitive PS1 (show PSEN1 ELISA Kits) modulator that could regulate synaptic ABETA, opening avenues for novel and selective synapse targeting therapeutic strategies.

  3. PrP (show C4BPA ELISA Kits)-Abeta oligomers binding might be the underlying mechanism of the prion (show PRNP ELISA Kits) diseases and Alzheimer's disease. [review]

  4. Bipolar disorder-mild cognitive impairment patients had a non-significant reduction in CSF (show CSF2 ELISA Kits) Abeta1-42 compared to controls, but this was still higher than in the Alzheimer disease group.

  5. the antibody NT4X is therapeutically beneficial in Alzheimer mouse models showing that N-truncated Abeta starting with position four in addition to pyroglutamate Abeta3-x is a relevant target to fight Alzheimer's disease.

  6. Sporadic Abeta accumulation may be partly associated with increased amyloidogenic APP production, especially in APOE (show APOE ELISA Kits) varepsilon4-negative subjects.

  7. Study identifies a common mechanism of transport into neurites of proteins linked to the pathology of Alzheimer's disease (i.e. sAPP) and ALS (show IGFALS ELISA Kits) (i.e. FUS (show FUS ELISA Kits), TDP-43 (show TARDBP ELISA Kits) and SOD1 (show SOD1 ELISA Kits))

  8. a considerable amount of evidence goes against the classical amyloid hypothesis and illustrates a new picture in which the Abeta loss of function, rather than its accumulation, has a pathogenic role in AD.

  9. The APP c.*331_*332del variant affected APP messenger RNA structure and binding of two microRNAs (miR (show MLXIP ELISA Kits)-582-3p and miR (show MLXIP ELISA Kits)-892b), providing a mechanism for the development of cerebral amyloid angiopathy.

  10. Astrocytic expression of the mutant APP is involved in the down-regulation of synaptic transmission in cell aging.

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 ELISA Kits)- and CD47 (show CD47 ELISA Kits)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE ELISA Kits) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. These data support the notion that APP and APLP2 (show APLP2 ELISA Kits) facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery.

  2. EphB2 (show EPHB2 ELISA Kits) prevents amyloid-beta-induced depletion of cell surface GluN1 (show GRIN1 ELISA Kits) requiring the PDZ (show INADL ELISA Kits)-binding motif of EphB2 (show EPHB2 ELISA Kits).

  3. Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.

  4. the absence of Mt3 reduces Abeta uptake in astrocytes through an abnormality in actin polymerization.

  5. Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS

  6. lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP/PS1 (show PSEN1 ELISA Kits) mice

  7. p38alpha (show MAPK14 ELISA Kits) MAPK (show MAPK1 ELISA Kits) plays a critical role in the regulation of BACE1 (show BACE ELISA Kits) degradation and Abeta generation in Alzheimer Disease pathogenesis

  8. Swedish mutant APP-based BACE1 (show BACE ELISA Kits) binding site peptide reduces APP beta-cleavage and cerebral Abeta levels in Alzheimer's mice.

  9. APP full length protein and/or its cleaved products are necessary to mount a complete and effective innate immune cell response to inflammatory injury.

  10. The study demonstrate that murine Abeta peptides have the capacity to produce amyloid deposits that are morphologically similar to deposits found in human AD provided the murine APP gene.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 ELISA Kits)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP ELISA Kits) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 ELISA Kits) and Aplp2 (show APLP2 ELISA Kits) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 ELISA Kits)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 ELISA Kits) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 ELISA Kits) signaling

APP Antigen Profile

Antigen Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl) Elisa Kit
  • amyloid beta (A4) precursor protein (APP) Elisa Kit
  • amyloid beta (A4) precursor protein (app) Elisa Kit
  • amyloid beta (A4) precursor protein (App) Elisa Kit
  • amyloid beta (A4) precursor protein a (appa) Elisa Kit
  • beta amyloid protein precursor (LOC100009546) Elisa Kit
  • AAA Elisa Kit
  • ABETA Elisa Kit
  • Abpp Elisa Kit
  • AD1 Elisa Kit
  • Adap Elisa Kit
  • Ag Elisa Kit
  • app Elisa Kit
  • APP-like Elisa Kit
  • APPI Elisa Kit
  • appl Elisa Kit
  • BcDNA:GH04413 Elisa Kit
  • betaApp Elisa Kit
  • CG7727 Elisa Kit
  • CTFgamma Elisa Kit
  • Cvap Elisa Kit
  • Dmel\\CG7727 Elisa Kit
  • E030013M08Rik Elisa Kit
  • EG:65F1.5 Elisa Kit
  • PN-II Elisa Kit
  • PN2 Elisa Kit
  • wu:fj34d10 Elisa Kit
  • wu:fk65e12 Elisa Kit
  • zgc:85740 Elisa Kit

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

GENE ID SPECIES
31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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