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Browse our APP (APP) ELISA Kits

Full name:
Amyloid beta (A4) Precursor Protein ELISA Kits (APP)
On www.antibodies-online.com are 97 Amyloid beta (A4) Precursor Protein (APP) ELISA Kits from 15 different suppliers available. Additionally we are shipping APP Antibodies (863) and APP Proteins (47) and many more products for this protein. A total of 1042 APP products are currently listed.
Synonyms:
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740

Top referenced APP ELISA Kits

  1. Human APP Primary Antibody for ELISA - ABIN414520 : Shi, Wu, Xu, Zou: Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. in Neurochemistry international 2011 (PubMed)
    Show all 2 references for ABIN414520

  2. Rat (Rattus) APP Primary Antibody for ELISA - ABIN810848 : Tian, Guo, Yue, Lv, Ye, Wang, Chen, Wu, Xu, Liu: Intranasal administration of nerve growth factor ameliorate ?-amyloid deposition after traumatic brain injury in rats. in Brain research 2012 (PubMed)

More ELISA Kits for APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (show GRIN2A ELISA Kits) recycling.

  2. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  3. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  4. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  5. APPL is the first example of a modulator of the Wnt (show WNT4 ELISA Kits)-PCP (show PRCP ELISA Kits) pathway specifically required for axon outgrowth.

  6. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 ELISA Kits) pathway through a mechanism mediated by PntP2 (show ETS2 ELISA Kits).

  7. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  8. Disruption of amyloid protein (show IAPP ELISA Kits) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  9. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 ELISA Kits)) reduces amyloid-beta production by altering Nicastrin (show NCSTN ELISA Kits) maturation and intracellular localization.

  10. accumulation of Ass42 plaques induces JNK (show MAPK8 ELISA Kits) signaling in neurons and induction of JNK (show MAPK8 ELISA Kits) contributes to Ass42 mediated cell death

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. APP may cooperate with c-KIT (show KIT ELISA Kits) mutation/overexpression in the regulation of cell apoptosis but not proliferation in AML1ETO-positive leukemia via the PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling pathway.

  2. the amyloid cascade hypothesis in Alzheimer disease should be expanded to include cross-interactions between Abeta and other amyloid proteins.

  3. This study reports the discovery of a TTR (show TTR ELISA Kits) mutant, N98A, that was more effective at inhibiting ABETA aggregation than wild-type (WT) TTR (show TTR ELISA Kits), although N98A and WT bound ABETA equally.

  4. Mice overexpressing the Swedish (K594M/N595L) mutation of human APP together with PS1 (show PSEN1 ELISA Kits) deleted in exon 9 were used in this study which traces age- and brain region-specific changes of glucose metabolic disorder, learning, and memory dysfunction in early Alzheimer's Disease using 18)F-labed fluorodeoxyglucose ((18)F-FDG (show SMUG1 ELISA Kits)) microPET.

  5. analysis of the structural basis linking alpha-helicity of the alpha/beta-discordant segment with the conformational conversion propensity of Abeta protein

  6. This article reviews the evidence for the role of the Alzheimer's disease -associated peptide ABETA in promoting inflammation and thrombosis in Alzheimer's disease via its interaction with the circulating proteins factor XII and fibrinogen. [review]

  7. The addition of recombinant heat-shock protein HSP70 (show HSP70 ELISA Kits) reduces TNFalpha (show TNF ELISA Kits) production induced by Abeta, which leads to a decrease in neuronal cell damage at the organism level.

  8. The effects of Abeta and its modified forms containing isomerized Asp7, phosphorylated Ser8, or both, were studied in SH-SY5Y human neuroblastoma (show ARHGEF16 ELISA Kits) cells. Asp7 isomerization of was shown to increase cytotoxicity of both the intact and phosphorylated Abeta.

  9. that Abeta1-42 oligomers could cause disturbances in insulin (show INS ELISA Kits)/Akt (show AKT1 ELISA Kits)/EAAT (show SLC1A2 ELISA Kits) signaling in astrocytes

  10. Three early-onset Alzheimer's disease (EOAD) causative genes (APP, PSEN1 (show PSEN1 ELISA Kits), and PSEN2 (show PSEN2 ELISA Kits)) were discovered in Asian countries. Most of the EOAD-associated mutations have been detected in PSEN1 (show PSEN1 ELISA Kits), and several novel PSEN1 (show PSEN1 ELISA Kits) mutations were recently identified in patients from various parts of the world, including Asia. [review]

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 ELISA Kits)- and CD47 (show CD47 ELISA Kits)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE ELISA Kits) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study further distinguishes two separate Abetao-dependent signaling cascades, one dependent on extracellular Ca(2 (show CA2 ELISA Kits)+) and Fyn (show FYN ELISA Kits) kinase activation and the other dependent on the release of Ca(2 (show CA2 ELISA Kits)+) from intracellular stores. Thus, Abetao triggers multiple distinct PrP(C (show PRNP ELISA Kits))-mGluR5 (show GRM5 ELISA Kits)-dependent events implicated in neurodegeneration and dementia.

  2. APP shares essential functions with APP-like protein-2 (APLP2 (show APLP2 ELISA Kits)) but not APP-like protein-1 (APLP1 (show APLP1 ELISA Kits)). Noteworthy, APLP2 (show APLP2 ELISA Kits), but not APLP1 (show APLP1 ELISA Kits), interacts with Stub1 (show STUB1 ELISA Kits) and CRL4(CRBN (show CRBN ELISA Kits)), pointing to a functional pathway shared only by APP and APLP2 (show APLP2 ELISA Kits).

  3. Orthopedic surgery induces Abeta accumulation and tau phosphorylation in the hippocampus.

  4. Results indicate that isomerization of Asp7 and phosphorylation of Ser8 of the amyloid beta peptide (Abeta) backbone have a significant impact on the profiles of brain Abeta binding proteins.

  5. Cadmium induces cell death on cholinergic neurons through blockade of M1 receptor, overexpression of AChE-S and GSK-3beta, down-regulation of AChE-R and increase in Abeta and total and phosphorylated tau protein levels.

  6. plasma Abeta(1-42) concentration increases with age, while the concentration of Abeta(1-42) in the cerebrospinal fluid (CSF (show CSF2 ELISA Kits)) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice.

  7. A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve (show PIKFYVE ELISA Kits) activity.

  8. APP, tau, and synaptophysin (show SYP ELISA Kits) were elevated in in the medial preoptic area in both the B6D2F1 and BXB1 maters relative to the B6D2F1 and BXB1 non-maters,suggesting a potential genetic mechanism for inheritance of steroid-independent male sexual behavior.

  9. folic acid deficiency can enhance Abeta accumulation in APP/PS1 (show PSEN1 ELISA Kits) mice brain and decrease amyloid-associated miRNAs expression

  10. These data support the notion that APP and APLP2 (show APLP2 ELISA Kits) facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 ELISA Kits)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP ELISA Kits) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 ELISA Kits) and Aplp2 (show APLP2 ELISA Kits) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 ELISA Kits)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 ELISA Kits) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 ELISA Kits) signaling

APP Antigen Profile

Antigen Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl) Elisa Kit
  • amyloid beta (A4) precursor protein (APP) Elisa Kit
  • amyloid beta (A4) precursor protein (app) Elisa Kit
  • amyloid beta (A4) precursor protein (App) Elisa Kit
  • amyloid beta (A4) precursor protein a (appa) Elisa Kit
  • beta amyloid protein precursor (LOC100009546) Elisa Kit
  • AAA Elisa Kit
  • ABETA Elisa Kit
  • Abpp Elisa Kit
  • AD1 Elisa Kit
  • Adap Elisa Kit
  • Ag Elisa Kit
  • app Elisa Kit
  • APP-like Elisa Kit
  • APPI Elisa Kit
  • appl Elisa Kit
  • BcDNA:GH04413 Elisa Kit
  • betaApp Elisa Kit
  • CG7727 Elisa Kit
  • CTFgamma Elisa Kit
  • Cvap Elisa Kit
  • Dmel\\CG7727 Elisa Kit
  • E030013M08Rik Elisa Kit
  • EG:65F1.5 Elisa Kit
  • PN-II Elisa Kit
  • PN2 Elisa Kit
  • wu:fj34d10 Elisa Kit
  • wu:fk65e12 Elisa Kit
  • zgc:85740 Elisa Kit

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

GENE ID SPECIES
31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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