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anti-Human LIM Domain Kinase 1 Antibodies:
anti-Rat (Rattus) LIM Domain Kinase 1 Antibodies:
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Human Polyclonal LIM Domain Kinase 1 Primary Antibody for EIA, IHC (p) - ABIN360142
Ohashi, Nagata, Maekawa, Ishizaki, Narumiya, Mizuno: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. in The Journal of biological chemistry 2000
Show all 5 references for ABIN360142
Human Monoclonal LIM Domain Kinase 1 Primary Antibody for IF, WB - ABIN968654
Edwards, Gill: Structural features of LIM kinase that control effects on the actin cytoskeleton. in The Journal of biological chemistry 1999
Show all 4 references for ABIN968654
Human Polyclonal LIM Domain Kinase 1 Primary Antibody for IHC (p), WB - ABIN392258
Maekawa, Ishizaki, Boku, Watanabe, Fujita, Iwamatsu, Obinata, Ohashi, Mizuno, Narumiya: Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. in Science (New York, N.Y.) 1999
Show all 4 references for ABIN392258
Human Polyclonal LIM Domain Kinase 1 Primary Antibody for ELISA, WB - ABIN1533778
Mizuno, Okano, Ohashi, Nunoue, Kuma, Miyata, Nakamura: Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motif. in Oncogene 1994
Show all 3 references for ABIN1533778
Human Polyclonal LIM Domain Kinase 1 Primary Antibody for IF, IHC (p) - ABIN196830
Edwards, Sanders, Bokoch, Gill: Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. in Nature cell biology 1999
Show all 2 references for ABIN196830
Chimpanzee Polyclonal LIM Domain Kinase 1 Primary Antibody for EIA, WB - ABIN401293
Yang, Yu, Hao, Li, Stewart, Insogna, Xu: LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1. in Nature cell biology 2004
This study showed that LIMK1 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples.
Gene knockdown/rescue experiments reveal that LIMK1 palmitoylation is essential for normal spine actin polymerization, for spine-specific structural plasticity and for long-term spine stability.
LIMK1 is overexpressed in endometrial stromal cells.
Data show that the downregulation of miR (show MLXIP Antibodies)-138 induced the upregulation of Limk1 in ovarian cancer (OC) cells suggesting that these 2 genes may play a key role in the migration and invasion of OC cells.
LIMK1 is overexpressed in gastric cancer.
Results show that in addition to a potential role in promoting metastasis, changes in LIMK1 and LIMK2 (show LIMK2 Antibodies) expression and/or activity might contribute to AR function in prostate cancer via regulation of microtubule cytoskeletal dynamics.
CXCL12 (show CXCL12 Antibodies)/CXCR4 (show CXCR4 Antibodies) signaling has a role in docetaxel-induced microtubule stabilization via p21-activated kinase 4 (show PAK4 Antibodies)-dependent activation of LIMK1
LIMK1 has a role in regulating human trophoblast invasion/differentiation and is down-regulated in preeclampsia
miR (show MLXIP Antibodies)-20a is involved in the tumor inhibition of cutaneous squamous cell carcinoma by directly targeting LIMK1 gene.
miR (show MLXIP Antibodies)-20a plays a role as a tumor suppressor in thyroid cancer cells and targets LIMK1
bone morphogenetic protein receptor II (BMPRII (show BMPR2 Antibodies)) is a major regulator of LIMK1 in extending RGC axons, as expression of a BMPRII (show BMPR2 Antibodies) lacking the LIMK1 binding region caused a dramatic shortening of the axons
Social isolation resulted in up-regulation of Limk-1 mRNA expression in the cerebral cortex.
The data emphasize the importance of the PLCeta2 EF-hand domain and articulation of PLCeta2 with LIMK-1 in regulating neuritogenesis.
Our study indicates that there is a connection between LIMK1 and AD in the mouse model of AD.
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
LIMK1 and Cofilin (show CFL1 Antibodies) phosphorylation depends on PKA and is essential for mouse sperm acrosomal exocytosis
These results provide strong evidence that LIMK1 deletion is sufficient to lead to a long-term memory deficit and that this deficit is attributable to CREB (show CREB1 Antibodies) hypofunction.
the conserved region in the LIMK1 3' UTR (show UTS2R Antibodies) is involved in regulating LIMK1 expression at the post-transcriptional level
LIMK1 plays a novel role in selectively mediating GPIb-IX-dependent TXA2 (show TBXA2R Antibodies) synthesis and thrombosis.
data support the hypothesis that LIMK1 is required for normal osteoblast differentiation. In addition, its absence leads to increased cytoskeletal remodeling and bone resorption in osteoclasts
LIMK1 has a dual role in regulating lamellipodium extension by decelerating actin retrograde flow and polymerization.
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
LIM domain kinase 1
, LIM motif-containing protein kinase
, LIM motif-containing protein kinase 1
, LIM-domain containing protein kinase 1
, LIM-domain containing, protein kinase 1