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|Antigen||TNFRSF1A-Associated Via Death Domain (TRADD) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This TRADD antibody is un-conjugated Alternatives|
Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-TRADD AntibodyTarget Details TRADD Application Details Handling References for anti-TRADD antibody (ABIN223257) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412952|
The antibody recognizes 34 kDa TRADD in samples from human, mouse, and rat origins.
Reactivity to other species has not been tested.
|Immunogen||Synthetic peptide surrounding amino acid 300 of human TRADD|
Target Details TRADDProduct Details anti-TRADD Antibody Application Details Handling References for anti-TRADD antibody (ABIN223257) Images back to top
|Alternative Name||TRADD (TRADD Antibody Abstract)|
TRADD (TNF-R1-associated death domain) is a 34 kDa protein that associates with the death domains of both FAS and TNF-R1 via their DDH regions. Overexpression of TRADD leads to NFκB activation and apoptosis in the absence of TNF.
Synonyms: MGC11078 , Hs.89862 , TNFR1
|Research Area||Cardiovascular, Atherosclerosis, Apoptosis/Necrosis|
|Pathways||NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C|
Application DetailsProduct Details anti-TRADD Antibody Target Details TRADD Handling References for anti-TRADD antibody (ABIN223257) Images back to top
|Application Notes||Western blotting (0.5-4 μg/mL). Based on researchers feedback, it also works well in immunoprecipitation (10-20 μg/mL) and Immunohistochemistry (15-25 μg/mL). However, the optimal concentrations should be determined individually. The antibody recognizes 34 kDa TRADD in samples from human, mouse, and rat origins. Reactivity to other species has not been tested. Mouse small intestine tissue lysate can be used as a positive control.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TRADD Antibody Target Details TRADD Application Details References for anti-TRADD antibody (ABIN223257) Images back to top
|Buffer||100 μg (0.2 mg/mL) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||The antibody solution should be gently mixed before use.|
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-TRADD antibody (ABIN223257)Product Details anti-TRADD Antibody Target Details TRADD Application Details Handling Images back to top
|Product cited in:||
Chen, Texada, Duggan, Liang, Reden, Kooragayala, Langford: "Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells." in: The Journal of biological chemistry, Vol. 280, Issue 23, pp. 22425-36, 2005
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