Browse our ALOX12B Proteins (ALOX12B)

Full name:
Arachidonate 12-Lipoxygenase, 12R Type Proteins (ALOX12B)
On www.antibodies-online.com are 7 Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) Proteins from 4 different suppliers available. Additionally we are shipping ALOX12B Antibodies (26) and ALOX12B Kits (1) and many more products for this protein. A total of 36 ALOX12B products are currently listed.
Synonyms:
12R-LOX, ALOX12B, Aloxe2, ARCI2, e-LOX2, MGC85124, MGC107915
list all proteins Gene Name GeneID UniProt
ALOX12B 242 O75342
ALOX12B 11686 O70582
ALOX12B 287425 Q2KMM4

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Human Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) interaction partners

  1. report adds information on the clinical picture of autosomal recessive congenital ichthyosis (show LBR Proteins) caused by ALOX12B mutations

  2. We found that the contribution of the ALOX12B gene to the pathogenesis of Autosomal Recessive Congenital Ichthyosis (show LBR Proteins) to be as important as that of TGM1 (show TGM1 Proteins) in families of Arab Muslim origin

  3. Loss-of-function mutations in the LOX (show LOX Proteins) genes ALOX12B and ALOXE3 (show ALOXE3 Proteins) have been found to represent the second most common cause of autosomal recessive congenital ichthyosis (show LBR Proteins). [review]

  4. This review covers the background to discovery of the two key lipoxygenases (LOX (show LOX Proteins)) involved in epidermal barrier function, 12R-LOX and eLOX3 (show ALOXE3 Proteins). [review]

  5. Autosomal recessive congenital ichthyosis (show LBR Proteins) patients with NIPAL4 (show NIPAL4 Proteins) mutations and abnormal ichthyin (show NIPAL4 Proteins) expression showed increased 12R-LOX and eLOX-3 (show ALOXE3 Proteins) staining and a colocalization signal of these LOXs that was three times the normal intensity.

  6. It was shown that 12R-lipoxygenase is involved in MUC5AC expression via ERK (show EPHB2 Proteins)- and Sp1 (show PSG1 Proteins)-signalling pathways.

  7. co-overproduction of the two chaperones with 12R-LOX resulted in increased solubility of 12R-LOX and allowed the purification of milligram amounts of active enzyme for structural studies by X-ray diffraction

  8. ALOX12B mutations are the leading cause of self-improving collodion ichthyosis (show LBR Proteins) in Scandinavia, followed by ALOXE3 (show ALOXE3 Proteins) mutations, and TGM1 (show TGM1 Proteins) mutations

  9. 12-R-LOX (show LOX Proteins) and COX-2 play critical roles in the regulation of growth in epidermoid carcinoma

  10. Lipoxygenase-3 (ALOXE3 (show ALOXE3 Proteins)) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.

Mouse (Murine) Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) interaction partners

  1. Loss-of-function mutations in the LOX (show LOX Proteins) genes ALOX12B and ALOXE3 (show ALOXE3 Proteins) have been found to represent the second most common cause of autosomal recessive congenital ichthyosis (show LBR Proteins). [review]

  2. The 12R-LOX-eLOX-3 (show ALOXE3 Proteins) pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing.

  3. Alox12b-deficient mouse skin transplants have an ichthyosiform phenotype

ALOX12B Protein Profile

Protein Summary

This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.

Alternative names and synonyms associated with ALOX12B

  • arachidonate 12-lipoxygenase, 12R type (ALOX12B)
  • arachidonate 12-lipoxygenase, 12R type (alox12b)
  • arachidonate 12-lipoxygenase, 12R type (Alox12b)
  • 12R-LOX protein
  • ALOX12B protein
  • Aloxe2 protein
  • ARCI2 protein
  • e-LOX2 protein
  • MGC85124 protein
  • MGC107915 protein

Protein level used designations for ALOX12B

arachidonate 12-lipoxygenase, 12R type , arachidonate 12-lipoxygenase, 12R-type , arachidonate 12-lipoxygenase, 12R type-like , arachidonate 12-lipoxygenase, 12R-type-like , 12R-lipoxygenase , epidermis-type lipoxygenase 12 , 12R-LOX , e-LOX 2 , epidermis-type lipoxygenase 2

GENE ID SPECIES
455103 Pan troglodytes
489486 Canis lupus familiaris
504803 Bos taurus
548458 Xenopus (Silurana) tropicalis
721936 Macaca mulatta
734312 Xenopus laevis
100062323 Equus caballus
100390364 Callithrix jacchus
100474976 Ailuropoda melanoleuca
100526246 Sus scrofa
242 Homo sapiens
11686 Mus musculus
287425 Rattus norvegicus
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