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In summary, we have identified three novel sequence variants, one in TGM1 (show TGM1 ELISA Kits) and two in ALOXE3, in three consanguineous families segregating lamellar ichthyosis (show LBR ELISA Kits) and congenital ichthyosiform erythroderma types of autosomal recessive congenital ichthyosis (show LBR ELISA Kits).
Case Report: homozygous ALOXE3 mutation causing autosomal recessive congenital ichthyosis (show LBR ELISA Kits).
Loss-of-function mutations in the LOX (show LOX ELISA Kits) genes ALOX12B (show ALOX12B ELISA Kits) and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis (show LBR ELISA Kits). [review]
This review covers the background to discovery of the two key lipoxygenases (LOX (show LOX ELISA Kits)) involved in epidermal barrier function, 12R-LOX (show ALOX12B ELISA Kits) and eLOX3. [review]
Autosomal recessive congenital ichthyosis (show LBR ELISA Kits) patients with NIPAL4 (show NIPAL4 ELISA Kits) mutations and abnormal ichthyin (show NIPAL4 ELISA Kits) expression showed increased 12R-LOX (show ALOX12B ELISA Kits) and eLOX-3 staining and a colocalization signal of these LOXs that was three times the normal intensity.
On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1.
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
ALOX12B (show ALOX12B ELISA Kits) mutations are the leading cause of self-improving collodion ichthyosis (show LBR ELISA Kits) in Scandinavia, followed by ALOXE3 mutations, and TGM1 (show TGM1 ELISA Kits) mutations
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B (show ALOX12B ELISA Kits)) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.
eLOX-3 hydrolase functions in the normal process of skin differentiation, and that the loss of function mutations are the basis of the LOX (show LOX ELISA Kits)-dependent form of Non-bullous congenital ichthyosiform erythroderma.
Aloxe3 deficiency in mice resulted in early postnatal death. Skin lipid analysis demonstrated that the severity of barrier failure is related to the loss of covalently bound ceramides in both ALOX12B (show ALOX12B ELISA Kits)- and Aloxe3-null mice.
expression of eLOX3 or addition of eLOX3 products stimulated adipogenesis under conditions that normally require an exogenous PPAR gamma (show PPARG ELISA Kits) ligand for differentiation
The substrate preference of mouse eLOX3 and the unique occurrence of an 8S-LOX (show ALOX15B ELISA Kits) enzyme in mouse skin point to a potential LOX (show LOX ELISA Kits) pathway for the production of epoxyalcohol in murine epidermal differentiation.
The 12R-LOX (show ALOX12B ELISA Kits)-eLOX-3 pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing.
findings suggest that endogenous PPARgamma (show PPARG ELISA Kits) ligand(s) promoting adipocyte differentiation are generated via a baicalein-sensitive pathway involving the novel eLOX-3
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.
arachidonate lipoxygenase 3
, epidermal lipoxygenase
, epidermis-type lipoxygenase 3
, arachidonate 15-lipoxygenase, type B