Browse our Cadherin 5 Proteins (CDH5)

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Cadherin 5 Proteins (CDH5)
On are 19 Cadherin 5 (CDH5) Proteins from 5 different suppliers available. Additionally we are shipping Cadherin 5 Antibodies (372) and Cadherin 5 Kits (67) and many more products for this protein. A total of 467 Cadherin 5 products are currently listed.
7B4, AA408225, cadherin-5, CD144, VE-Cad, Vec, VEcad, VECD, wu:fc88a07
list all proteins Gene Name GeneID UniProt
CDH5 12562 P55284
CDH5 307618  
CDH5 1003 P33151

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Cadherin 5 Proteins (CDH5) by Origin

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Top referenced Cadherin 5 Proteins

  1. Mouse (Murine) Cadherin 5 Protein expressed in Human Cells - ABIN2007491 : Angst, Marcozzi, Magee: The cadherin superfamily: diversity in form and function. in Journal of cell science 2001 (PubMed)
    Show all 5 references for 2007491

  2. Human Cadherin 5 Protein expressed in Human Cells - ABIN2002841 : Duguay, Foty, Steinberg: Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants. in Developmental biology 2003 (PubMed)
    Show all 5 references for 2002841

  3. Rat (Rattus) Cadherin 5 Protein expressed in Human Cells - ABIN2009411 : Bayas, Leung, Evans, Leckband: Lifetime measurements reveal kinetic differences between homophilic cadherin bonds. in Biophysical journal 2006 (PubMed)
    Show all 4 references for 2009411

More Proteins for Cadherin 5 Interaction Partners

Mouse (Murine) Cadherin 5 (CDH5) interaction partners

  1. Galphas (show GNAS Proteins) depletion blocks the S1PR1 (show S1PR1 Proteins)-activation induced VE-cadherin stabilization at junctions.

  2. Rab11a/Rab11 (show RAB11A Proteins) family-interacting protein 2 (show RAB11FIP2 Proteins)-mediated VE-cadherin recycling is required for formation of adherens junctions and restoration of vascular endothelial barrier integrity.

  3. These findings together demonstrate the essential role of KDM4A (show KDM4A Proteins) and KDM4C (show KDM4C Proteins) in orchestrating mESC differentiation to endothelial cells through the activation of Flk1 (show KDR Proteins) and VE-cadherin promoters, respectively

  4. In the absence of Tie-2 (show TEK Proteins), VE-PTP (show PTPRB Proteins) inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin-supportive effect of VE-PTP (show PTPRB Proteins).

  5. identification of novel components of the adherens junction complex, and introduction of a novel molecular mechanism through which the VE-cadherin complex controls YAP (show YAP1 Proteins) transcriptional activity

  6. Endotoxin challenge initiates interrelated changes in microvessel Cx43 (show GJA1 Proteins), VE-cadherin, and microvessel permeability, with changes in Cx43 (show GJA1 Proteins) temporally leading the other responses.

  7. Mutating Y731 in the cytoplasmic tail of VE-cadherin, known to selectively affect leukocyte diapedesis, but not the induction of vascular permeability, attenuates bleeding.

  8. mRNA of HIF-2alpha (show EPAS1 Proteins) and Ets-1 (show ETS1 Proteins) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin

  9. iPS (show SLC27A4 Proteins) cell-derived Flk1 (show KDR Proteins)(+)VE-cadherin(+) cells expressing the Er71 (show ETV2 Proteins) are as angiogenic as mES (show PTCH1 Proteins) cell-derived cells and incorporate into CD31 (show PECAM1 Proteins)(+) neovessels.

  10. VE-cadherin tyrosine phosphorylation at Y685 is a physiological and hormonally regulated process in female reproductive organs.

Zebrafish Cadherin 5 (CDH5) interaction partners

  1. VE-cadherin and Esama (show ESAM Proteins) have distinct and redundant functions during blood vessel morphogenesis

  2. C1qr (show CD93 Proteins) and c1qrl regulate angiogenesis through controlling endothelial cdh5 expression.

  3. the conserved targeting of VE-cadherin by miR (show MYLIP Proteins)-22 regulates endothelial inflammation, tissue injury, and angiogenesis.

  4. VE-cadherin/amotL2 (show AMOTL2 Proteins) complex is responsible for transmitting mechanical force between endothelial cells for the coordination of cellular morphogenesis consistent with aortic lumen expansion and function.

  5. Cdh5 organizes junctional and cortical actin cytoskeletons and F-actin polymerization during endothelial cell elongation.

  6. Regulatory pathways affecting vascular stabilization via VE-cadherin dynamics

  7. suggest that Ve-cadherin and Moesin1 (show MSN Proteins) function to establish and maintain apical/basal polarity during multicellular lumen formation in the intersegmental vessels

  8. results demonstrate a significant role for VE-cadherin in cardiac development independent of its effects on the formation of the peripheral vasculature

  9. fli1 (show FLI1 Proteins), and etsrp (show ETV2 Proteins), demonstrated that erg (show KCNH2 Proteins) and fli1 (show FLI1 Proteins) act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin

  10. VE-cadherin plays an essential role in vascular development

Human Cadherin 5 (CDH5) interaction partners

  1. Cells in high glucose for 7 days showed a significant decrease in mRNA expression of CD31 (show HBA1 Proteins) and VE-cadherin, and a significant increase in that of alpha-SMA (show SMN1 Proteins) and collagen I.

  2. AngII could induce pulmonary injury by triggering endothelial barrier injury, and such process may be related to the dephosphorylation of Y685-VE-cadherin and the endothelial skeletal rearrangement

  3. Breast cancer-secreted miR (show MLXIP Proteins)-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers.

  4. EGFR (show EGFR Proteins) genes are associated with overexpression of CDH5 through increased phosphorylation of EGFR (show EGFR Proteins) and downstream Akt (show AKT1 Proteins) pathways.

  5. We found that patients with chronic spontaneous urticaria (CSU) had significantly higher CDH5 serum levels compared with patients with atopic dermatitis and control subjects. Moreover, serum levels ofCDH5 were closely associated with the severity of CSU.

  6. Results indicate that the posthemorrhagic shock mesenteric lymph in vitro increases the cellular permeability of human umbilical vein endothelial cells through suppression of F-actin and VE-cadherin.

  7. CMTM3 (show CMTM3 Proteins) mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting by regulation VE-cadherin turnover.

  8. Serum CDH5 correlates to poorer survival in patient with hormone-refractory metastatic breast cancer.

  9. Lateral accumulation of cadherin fingers in follower cells precedes turning, and increased actomyosin contractility can initiate cadherin finger extension as well as engulfment by a neighbouring cell, to promote follower behaviour.

  10. the conserved targeting of VE-cadherin by miR (show MLXIP Proteins)-22 regulates endothelial inflammation, tissue injury, and angiogenesis.

Cow (Bovine) Cadherin 5 (CDH5) interaction partners

  1. VE-cadherin induces opposing growth signals.

  2. investigated the role of catenin p120 (show CTNND1 Proteins)-VE-cadherin interaction in regulation of barrier function in confluent endothelial monolayers

  3. Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA (show RHOA Proteins)

  4. a VE-cadherin-dependent pathway may link T2-TrpRS (show WARS Proteins) to inhibition of new blood vessel formation

  5. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network

  6. exposure of BAECs to hydrostatic pressure (PHYSIOLOGIC PRESSURE) may downregulate the expression of VE-cadherin, resulting in loss of contact inhibition followed by increased proliferation and formation of a multilayered structure

  7. In all, these results demonstrate that cell-cell contact signals through VE-cadherin, RhoA, and intracellular tension in the actin cytoskeleton to regulate proliferation.

Pig (Porcine) Cadherin 5 (CDH5) interaction partners

  1. Low expressions of eNOS3 and Ve-cadherin in the salvaged sub-healthy microvascular endothelium of infarcted and marginal areas suggest that endothelial system is impaired at 7-day of reperfused acute myocardial infarction.

Cadherin 5 (CDH5) Protein Profile

Protein Summary

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.

Alternative names and synonyms associated with Cadherin 5 (CDH5)

  • cadherin 5, type 2 (vascular endothelium) (CDH5)
  • cadherin 5 (Cdh5)
  • cadherin 5 (cdh5)
  • cadherin 5, type 2 (vascular endothelium) (Cdh5)
  • 7B4 protein
  • AA408225 protein
  • cadherin-5 protein
  • CD144 protein
  • VE-Cad protein
  • Vec protein
  • VEcad protein
  • VECD protein
  • wu:fc88a07 protein

Protein level used designations for Cadherin 5 Proteins (CDH5)

cadherin 5, type 2, VE-cadherin (vascular endothelium) , cadherin 5, type 2, VE-cadherin (vascular epithelium) , 7B4/cadherin-5 , VE-cadherin , cadherin-5 , vascular endothelial cadherin , VE-cadherin (vascular epithelium) , fc88a07 , type 2 , vecdn , 7B4 antigen , cd144 antigen , endothelial-specific cadherin , VE cadherin

467991 Pan troglodytes
12562 Mus musculus
307618 Rattus norvegicus
445471 Danio rerio
1003 Homo sapiens
414735 Bos taurus
100727685 Cavia porcellus
414737 Sus scrofa
489775 Canis lupus familiaris
374068 Gallus gallus
101107462 Ovis aries
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