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Nectin (show PVRL1 Proteins)-based cell-cell adhesion was formed at the apical side of the junctional adhesion molecule (show AMICA1 Proteins) (JAM (show F11R Proteins))-based cell-cell adhesion; cadherin and claudin were recruited to the nectin-3 (show PVRL3 Proteins) and JAM (show F11R Proteins)-based cell-cell adhesion sites to form AJ- and TJ-like domains.
NECL1 can inhibit the migration and invasion of glioma cells and induce differentiation.
Findings clearly reveal the structural basis for the cis (show CISH Proteins)-dimerization of nectins through the first Ig-like domains.
A link might exist between NECL1 and the extracellular matrix protein OPN (show SPP1 Proteins) in inhibiting the migration and invasion of U251 glioma ce
NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis.
Nec- 1 (show PCSK1 Proteins) suppress the growth and tumorigenic ability of colon cancer cells.
Necl-1 is a neural-tissue-specific Ca2 (show CA2 Proteins)+-independent immunoglobulin-like cell-cell adhesion molecule (show PCDHB16 Proteins) which potentially has membrane-associated guanylate kinase (show GUK1 Proteins) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
crystallographic analysis of human Nectin (show PVRL1 Proteins)-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule (show PCDHB16 Proteins)
human NECL1 is an N-linked glycoprotein with a single glycosylation site at position N290KS
Expression of entry receptors nectin-1 (show PVRL1 Proteins) and HVEM (show TNFRSF14 Proteins) prevent entry of HSV-1 into human conjunctival epithelium.
Our results suggest that Cadm3 may act as a negative regulator of peripheral nerve myelination, potentially through the selective regulation of the signaling cascades activated in Schwann cells by axonal contact, and in particular by type III Nrg-1 (show NRG1 Proteins).
Necl-1 is a neural-tissue-specific Ca2 (show CA2 Proteins)+-independent immunoglobulin-like cell-cell adhesion molecule (show PCDHb5 Proteins) which potentially has membrane-associated guanylate kinase (show GUK1 Proteins) subfamily member-binding activity and localizes at the non-junctional cell-cell contact sites
Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.
finding suggests that NECL1 may act as a tumor suppressor in glioma and loss of it in glioma may be caused by histone deacetylation
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3\; MIM 607147) (Kakunaga et al., 2005
, TSLC1-like protein 1
, brain immunoglobulin receptor
, dendritic cell nectin-like protein 1 short isoform
, immunoglobulin superfamily member 4B
, immunoglobulin superfamily, member 4B
, nectin-like 1
, nectin-like protein 1
, synaptic cell adhesion molecule 3
, nectin-lke 1