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Human Claudin 1 Protein expressed in Wheat germ - ABIN1349581
Broussard, Kim, Wiley, Marquez, Annis, Pritchard, Disis: Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions. in Cancer prevention research (Philadelphia, Pa.) 2013
Show all 5 Pubmed References
Tumor necrosis factor-alpha (show TNF Proteins) increases claudin-1, 4, and 7 expression in renal tubular cells, altering permeability and transepithelial electrical resistance.
Cyclosporine A/sirolimus alter claudin-1 expression in renal proximal tubular cells via ERK1/2 signaling pathway to alter barrier function.
These findings indicate a previously unrecognized mechanism that miR (show MLXIP Proteins)-142-5p, targeting CLDN1, plays an important role in Hashimoto's thyroiditis pathogenesis.
Here, the authors identified an interaction between claudin-1 (show CLDN7 Proteins) and Sec24C (show SEC24C Proteins), a cargo-sorting component of the coat protein (show GOLPH3 Proteins) complex II (COPII) vesicular transport system.
Aberrant expression of the tight junction molecules claudin-1 (show CLDN7 Proteins) and zonula occludens-1 (show TJP1 Proteins) mediates cell growth and invasion in oral squamous cell carcinoma cells.
Increased expression of intestinal epithelial claudin-1 (show CLDN7 Proteins) with downregulation of claudin-3 (show CLDN3 Proteins) has been observed in intestinal inflammatory disorders.
Studies indicate claudin 1 (CLDN-1) as a target for improving epidermal drug absorption and preventing HCV infection and of claudin 4 (CLDN-4 (show CLDN4 Proteins)) as a target for anticancer therapeutics.
Data show that the charge of Lys65 in claudin 1 (Cldn1) and Glu158 in claudin 3 (Cldn3 (show CLDN3 Proteins)), and of Gln57 in claudin 5 (Cldn5 (show CLDN5 Proteins)) are necessary for tight junction (TJ) strand formation.
Studies indicate that claudin-1 (show CLDN7 Proteins) accumulate in early endosomes in both epithelial and endothelial cells.
These results revealed that CLDN1 contributed to cancer stem cell features of hepatocellular carcinoma, which was altered by TMPRSS4 expression via ERK1/2 signaling pathway, providing promising targets for novel specific therapies.
Data suggest that epithelial-mesenchymal transition (EMT (show ITK Proteins)) is regulated by ZMYND8 (receptor for activated protein kinase C (show GNB2L1 Proteins)) which selectively activates gene promoters of CLDN1 (claudin 1) and CDH1 (E-cadherin (show CDH1 Proteins)) in breast cancer cells; thus, the presence of ZMYND8 could be implicated in maintaining epithelial phenotype of cells; ZMYND8 regulates invasion/migration of breast cancer cells.
The data suggested that miR (show MLXIP Proteins)-29a may regulate tumor growth and migration by targeting CLDN1.
Taken together, these results demonstrate that BTZ (show CASC3 Proteins)-induced claudin 1 expression may be a valuable therapeutic approach for AD.
Results suggest that TLR4 (show TLR4 Proteins)-dependent claudin-1 internalization and secondary anion secretion contribute to irinotecan-induced diarrhea.
Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (show PRRX1 Proteins) (Msx) genes Msx1d/d/Msx2d/d uteri.
Cldn-1 is a positive regulator of osteoblast proliferation and differentiation.
We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions.
MIR29 targets and reduces expression of CLDN1 and NKRF (show NKRF Proteins) to increase intestinal permeability in inflammatory bowel disease.
Occludin (show OCLN Proteins) and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis.
regulates intestinal epithelial homeostasis via regulation of Notch (show NOTCH1 Proteins)-signalling
Downregulation of Sirt1 (show SIRT1 Proteins) and upregulation of the tight junction protein Claudin-1 by SIRT1 (show SIRT1 Proteins)-mediated epigenetic regulation in podocytes contributed to albuminuria.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
, claudin 19
, claudin 1
, senescence-associated epithelial membrane protein 1
, tight junction protein