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Human Claudin 1 Protein expressed in Wheat germ - ABIN1349581
Broussard, Kim, Wiley, Marquez, Annis, Pritchard, Disis: Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions. in Cancer prevention research (Philadelphia, Pa.) 2013
Show all 5 references for ABIN1349581
Cyclosporine A/sirolimus alter claudin-1 expression in renal proximal tubular cells via ERK1/2 signaling pathway to alter barrier function.
hypotonic stress induces dephosphorylation, clathrin-dependent endocytosis, and degradation of claudin-1 (show CLDN7 Proteins) and -2 in lysosomes, resulting in disruption of the TJ barrier in renal tubular epithelial cells.
TNF-alpha (show TNF Proteins) mediated regulation of claudin-1 (show CLDN7 Proteins) and tumorigenic abilities of colon cancer cells.
CLDN1 is significantly hypomethylated in tumor samples and that the membrane staining intensity for claudin 1 (show CLDN7 Proteins), 4, and 7 is significantly lower in colorectal cancer tissues than in adjacent nonneoplastic tissue.
CLDN1 rather than variants in FLG (show FGFR1 Proteins) may be involved in the susceptibility of AD in the Ethiopian population
CLDN1 overexpression is a good prognostic factor in NSCLC.
Studies showthat CLDN1 is downregulated in lung adenocarcinoma and that low CLDN1 messenger ribonucleic acid (mRNA) expression leads to shorter overall survival.
The loss of claudin-1 (show CLDN7 Proteins) appears to be involved in the pathogenesis of pterygium
autotypic tight junctions molecular composition, like claudin-1 (show CLDN7 Proteins) and occludin (show OCLN Proteins) expression could influence the demyelinating process by altering the permeability of the blood-nerve barrier.
High CLDN1 expression is associated with Cervical cancer.
Claudin-1 (show CLDN7 Proteins) expression was correlated with lymphatic microvessel generation in hypopharyngeal squamous cell carcinoma and with patient survival.
Data show that the spatiotemporal expression of claudin-1 is dysregulated in homeobox (show PRRX1 Proteins) (Msx) genes Msx1d/d/Msx2d/d uteri.
Cldn-1 is a positive regulator of osteoblast proliferation and differentiation.
We further demonstrate that KRT76 interacts with CLDN1 and propose that this interaction is necessary to correctly position CLDN1 in tight junctions.
MIR29 targets and reduces expression of CLDN1 and NKRF (show NKRF Proteins) to increase intestinal permeability in inflammatory bowel disease.
Occludin (show OCLN Proteins) and Claudin-1 expressions in the large intestine are under the circadian control, which is associated with temporal regulation of colonic permeability and also susceptibility to colitis.
regulates intestinal epithelial homeostasis via regulation of Notch (show NOTCH1 Proteins)-signalling
Downregulation of Sirt1 (show SIRT1 Proteins) and upregulation of the tight junction protein Claudin-1 by SIRT1 (show SIRT1 Proteins)-mediated epigenetic regulation in podocytes contributed to albuminuria.
Cldn1(-/-) mice exhibited the abnormal stratum granulosum formation and stratum corneum barrier defects.
miR (show MLXIP Proteins)-155 may prevent tumorigenesis in human ovarian cancer through downregulation of CLDN1
Claudin-1 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, dark cell area.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
, claudin 19
, claudin 1
, senescence-associated epithelial membrane protein 1
, tight junction protein