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Human Desmoglein 2 ELISA Kit for Sandwich ELISA - ABIN417921
Pillai, Sankoorikal, Johnson, Seneviratne, Zurko, Brown, Hathout, Rose: Directional secretomes reflect polarity-specific functions in an in vitro model of human bronchial epithelium. in American journal of respiratory cell and molecular biology 2014
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these data suggest that palmitoylation of Dsg2 regulates protein transport to the plasma membrane. Modulation of the palmitoylation status of desmosomal cadherins can affect desmosome dynamics.
Both Dsg2 mRNA and protein were highly expressed in non-small cell lung cancer (NSCLC) tissues and associated with NSCLC size, but not with overall survival of patients.
a novel pathway of CSTA (show CSTA ELISA Kits) regulation involving Dsg2
DSG2 and DSG3 (show DSG3 ELISA Kits) might be potential diagnostic markers for squamous cell carcinoma of the lung.
In endometrial luminal epithelium, cadherin 6 (show CDH6 ELISA Kits), desmoglein 2 and plexin b2 (show PLXNB2 ELISA Kits) were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.
a low DSG2 expression phenotype is a useful prognostic biomarker of tumor aggressiveness and may serve as an aid in identifying patients with clinically significant prostate cancer.
Six variants of uncertain clinical significance in the PKP2 (show PKP2 ELISA Kits), JUP (show JUP ELISA Kits), and DSG2 genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 ELISA Kits)/C-related pathogenic splice site mutations.
This structure reveals that the ectodomain of Dsg2 is flexible even in the calcium-bound state and, on average, is shorter than the type 1 cadherin crystal structures.
Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 (show DSC2 ELISA Kits) play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR (show EGFR ELISA Kits) signaling.
Desmoglein 2 expression attenuates migration of melanoma cells, mediated by downregulation of secretogranin II (show SCG2 ELISA Kits).
Data suggest that loss of desmoglein 2 (Dsg2) compromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other desmosome-related arrhythmogenic cardiomyopathy (AC).
Dsg2 modulates Gli1 (show GLI1 ELISA Kits) expression. Dsg2-mediated hyperproliferation, MEK (show MDK ELISA Kits)/Erk1/2 (show MAPK1/3 ELISA Kits) activation, and accelerated squamous tumor development are enhanced on the Ptc1 (show PTCH1 ELISA Kits)+/lacZ (show GLB1 ELISA Kits) background.
Data demonstrate that desmoglein-2 plays a critical role in cardiomyocyte cohesion and function.
Dsg2 compensates for Dsg3 (show DSG3 ELISA Kits) depletion with regard to cell cohesion, but does not regulate p38 MAPK (show MAPK14 ELISA Kits) signaling.
In vivo interaction between Dsg2 and Na(V)1.5 provides a molecular pathway for the observed electrical disturbances during the early arrhythmogenic right ventricular cardiomyopathy.
Mutant desmoglein 2 cannot support the increased requirements placed on intercalated disc adhesion during postnatal heart development. This induces cardiomyocyte death, aseptic inflammation and fibrotic replacement.
ventricular arrhythmias that has been linked to mutations in desmosomal proteins including desmoglein 2
Myocyte necrosis underlies progressive myocardial dystrophy in N271S-dsg2-related arrhythmogenic right ventricular cardiomyopathy.
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
, Dsg alpha
, desmocollin a
, cadherin family member 5