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anti-Human F2RL2 Antibodies:
anti-Mouse (Murine) F2RL2 Antibodies:
anti-Rat (Rattus) F2RL2 Antibodies:
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PAR3 is essential in thrombin (show F2 Antibodies) stimulated insulin (show INS Antibodies) secretion.
TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (show NOS3 Antibodies)-Thr (show TRH Antibodies)-495 with minimal phosphorylation of eNOS (show NOS3 Antibodies)-Ser (show SIGLEC1 Antibodies)-1177 with no change in nitric oxide production.
These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR (show JTB Antibodies) activation, such as the activation of vascular-protective Tie2 (show TEK Antibodies) by noncanonical PAR3 activation.
In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin (show CDH1 Antibodies), leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav.
Data indicate that knockdowns of all three PARs (show EPRS Antibodies) PAR-1 (show MARK2 Antibodies), PAR-2 (show F2RL1 Antibodies), and PAR-3 exhibited changes in the expression of CDC42 (show CDC42 Antibodies), which correlated with the changes in their invasion.
Elevated expression of PAR-3, b (show MARK2 Antibodies)ut not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients.
A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C (show PROC Antibodies) cytoprotective effects.
PAR-3 receptors interact with thrombin (show F2 Antibodies) and increase heme oxygenase-1 (show HMOX1 Antibodies) expression in synovial fibroblasts.
Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR (show ELAVL1 Antibodies), whereas transcriptional control involves nuclear factor of activated T cells (NFAT (show NFATC1 Antibodies)).
FXa (show F10 Antibodies) bound in a punctate manner to thrombi under shear, while thrombin (show F2 Antibodies) and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi
Data show that activated protein C (show PROC Antibodies) signals via protease activated receptors PAR2 (show F2RL1 Antibodies)/PAR3 to expand Treg cells, mitigating the disease in mice.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2 (show IQGAP2 Antibodies)) and F2rl2
Simultaneous depletion of PAR-1 (show MARK2 Antibodies) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
these data point to a novel kallikrein 6 (show KLK1 Antibodies) -signaling axis in neurons that is mediated by PAR1 (show F2R Antibodies) and PAR2 (show F2RL1 Antibodies) and is positioned to contribute to neurodegeneration
Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (show F3 Antibodies)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)
PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (show F2R Antibodies)-type thrombin (show F2 Antibodies) receptors
Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (show F2RL3 Antibodies) by the active site of thrombin (show F2 Antibodies).
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.
CTCL tumor antigen se2-5
, atypical PKC isotype-specific interacting protein
, atypical PKC isotype-specific-interacting protein
, par-3 family cell polarity regulator alpha
, par-3 partitioning defective 3 homolog
, partitioning defective 3 homolog
, Coagulation factor II receptor-like 2 (protease-actovated receptor 3)
, protease-activated receptor 3
, proteinase-activated receptor 3
, proteinase-activated receptor-3
, thrombin receptor-like 2
, Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
, coagulation factor II receptor-like 2
, coagulation factor II (thrombin) receptor-like 2 L homeolog