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Chicken Monoclonal JUP Primary Antibody for IF, IP - ABIN967859
Mary, Charrasse, Meriane, Comunale, Travo, Blangy, Gauthier-Rouvière: Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism. in Molecular biology of the cell 2002
Show all 5 Pubmed References
Chicken Monoclonal JUP Primary Antibody for IF, IP - ABIN967860
Merritt, Berika, Zhai, Kirk, Ji, Hardman, Garrod: Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. in Molecular and cellular biology 2002
Show all 5 Pubmed References
Human Monoclonal JUP Primary Antibody for IF, IP - ABIN2191996
Amitay, Nass, Meitar, Goldberg, Davidson, Trakhtenbrot, Brok-Simoni, Ben-Zeev, Rechavi, Kaufmann: Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma. in The American journal of pathology 2001
Show all 4 Pubmed References
Human Polyclonal JUP Primary Antibody for ELISA, WB - ABIN249574
Knudsen, Wheelock: Plakoglobin, or an 83-kD homologue distinct from beta-catenin, interacts with E-cadherin and N-cadherin. in The Journal of cell biology 1992
Human Monoclonal JUP Primary Antibody for ICC, IHC - ABIN969225
Shair, Schnegg, Raab-Traub: Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. in Cancer research 2009
Human Monoclonal JUP Primary Antibody for ELISA, ICC - ABIN4313351
Seo, Sakon, Nakazawa, Nishioka, Watanabe, Matsumoto, Akasaka, Shioi, Sawada, Araki: Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo. in The FEBS journal 2017
Human Monoclonal JUP Primary Antibody for FACS, IF - ABIN5581414
Sacco, McGranahan, Wheelock, Johnson: Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. in The Journal of biological chemistry 1995
We showed that p53 (show TP53 Antibodies) and PG cooperatively reduced growth and acted synergistically to decrease cellular migration and invasion
High plakoglobin expression is associated with lung adenocarcinoma.
Knockdown of GATA6 (show GATA6 Antibodies) completely eliminated the effect of TCF1 (show HNF1A Antibodies), while forced expression of GATA6 (show GATA6 Antibodies) induced hESC differentiation
Studies indicate that the small molecule ICG-001 selectively blocks the cAMP response element-binding (CREB (show CREB1 Antibodies)) protein (CBP (show CREBBP Antibodies))/beta-catenin (show CTNNB1 Antibodies) or gamma-catenin interaction.
Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF (show VEGFA Antibodies)-induced phosphorylation of VE-cadherin (show CDH5 Antibodies)
In JUP mutations are the frequent cause of Arrhythmogenic cardiomyopathy, isolated Brugada syndrome can appear due to reduced sodium channel activities.
investigated the in vitro tumor/metastasis suppressor effects of plakoglobin in ovarian cancer cell lines with mutant p53 expression and different cadherin profiles
Reduced plakoglobin staining in intercalated discs of heart tissue from human arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and in a murine ARVC model is caused by alterations in epitope accessibility and not by protein relocalization
Idiopathic pulmonary fibrosis lung fibroblasts expressed less Pkgb protein than control fibroblasts, but characteristic fibroblast phenotypes (adhesion, proliferation, and apoptosis) were not controlled by Pkgb expression.
Immunostaining for plakoglobin might serve as an additional diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology.
Mice with hepatic loss of the desmosomal protein gamma-Catenin are prone to cholestatic injury and chemical carcinogenesis.
EMMPRIN ensures proper actomyosin-driven maturation of competent endothelial junctions by forming a molecular complex with gamma-catenin (also known as junction plakoglobin) and Nm23 (also known as NME1), a nucleoside diphosphate kinase
In 2 knockin mouse models, endogenous Jup was engineered to express the Naxos-associated form of plakoglobin. Insufficiency of the truncated Naxos plakoglobin, rather than gain of function, accounted for cardiac disease manifestations.
plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1 (show LEF1 Antibodies)) differentially regulates the proximal promoters of Dsc2 (show DSC2 Antibodies) and Dsc3 (show DSC3 Antibodies)
our study reveals a function for gamma-catenin in the regulation of mESC differentiation and has implications for human cancers in which gamma-catenin is mutated and/or aberrantly expressed.
The data suggest novel function(s) for plakoglobin (PG) beyond the heart and define a critical threshold of PG expression that is necessary for postnatal survival.
decreased plakoglobin expression increases the invasive behavior of breast cancer cells; this is the first demonstration of a functional role for plakoglobin/gamma-catenin in the metastatic process
The cadherin-catenin signaling pathway was inactivated in spinal motor neurons to assess the significance of motor neuron position in motor circuit assembly; genetic inactivation of both beta- and gamma-catenin or N-cadherin (show CDH2 Antibodies), disrupts motor neuron positioning.
Lack of plakoglobin in epidermis leads to keratoderma.
Although plakoglobin is clearly present during normal odontogenesis, the loss of plakoglobin does not influence tooth development.
plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development
knockdown of plakoglobin in zebrafish results in decreased heart size, reduced heartbeat, cardiac oedema, reflux of blood between heart chambers and a twisted (show POMT2 Antibodies) tail
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene\; however, not all transcripts have been fully described.
, junction plakoglobin
, Junction plakoglobin
, junction plakoglobin-like
, catenin (cadherin-associated protein), gamma 80kDa
, desmoplakin III
, gamma-catenin (plakoglobin)