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Study found that in peripheral blood mononuclear cells the median expression of KIFC3, KIF1B (show KIF1B ELISA Kits), and KIF5C was much lower than the expression of dynactin (show DCTN1 ELISA Kits) subunits DCTN1 (show DCTN1 ELISA Kits) and DCTN3 (show Dctn3 ELISA Kits), in both sporadic amyotrophic lateral sclerosis and healthy cases
Data indicate that E-cadherin (show CDH1 ELISA Kits) ubiquitination consistently increases after depletion of kinesin-like protein KIFC3 or ubiquitin-specific protease USP47 (show USP47 ELISA Kits).
KIFC3 may guide free microtubules to their destination at the bridge and/or may slide and crosslink central bridge microtubules in order to stage the cells for abscission.
KifC3 may play a regulatory role in minus-end directed peroxisomal transport for example by blocking the motor function of dynein at peroxisomes.
High expression of KIFC3 is associated with docetaxel resistance in breast cancer.
KIFC3 plays a complementary role in Golgi positioning and integration
KIFC3 belongs to the large superfamily of kinesins, molecular motors that use the energy of ATP hydrolysis to translocate cargoes along microtubules. Members share extensive homology within a globular domain containing the microtubule- and ATP-binding sites and have a coiled-coil stalk domain that mediates oligomerization. Different kinesin family members participate in specific and diverse motile processes, such as cell division, organelle transport, and nuclear movement (Hoang et al., 1998
novel kinesin motor domain containing protein
, kinesin family member C3
, kinesin-like protein KIFC3