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anti-Human Laminin alpha 5 Antibodies:
anti-Mouse (Murine) Laminin alpha 5 Antibodies:
anti-Rat (Rattus) Laminin alpha 5 Antibodies:
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Human Monoclonal Laminin alpha 5 Primary Antibody for ELISA, WB - ABIN561641
Maynard, Heijnen, Horne, White, Gahl: Proteomic analysis of platelet alpha-granules using mass spectrometry. in Journal of thrombosis and haemostasis : JTH 2007
Show all 4 Pubmed References
Human Polyclonal Laminin alpha 5 Primary Antibody for ELISA - ABIN4229153
De Luca, Crocco, Wiener, Tiwari, Passarino, Rose: Association of a common LAMA5 variant with anthropometric and metabolic traits in an Italian cohort of healthy elderly subjects. in Experimental gerontology 2010
Human Polyclonal Laminin alpha 5 Primary Antibody for ELISA, WB - ABIN561640
Kariya, Sato, Katou, Kariya, Miyazaki: Polymerized laminin-332 matrix supports rapid and tight adhesion of keratinocytes, suppressing cell migration. in PLoS ONE 2012
We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 subunit gene (LAMA5). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1 (show LAMA1 Antibodies), had muscle weakness, myopia, and facial tics
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 (show ITGA3 Antibodies) and ITGA2B), collagen ( COL5A1 (show COL5A1 Antibodies)), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.
The Laminin-511 consists of alpha5, beta1, and gamma1 chains, of which three laminin globular domains of the alpha5 chain (alpha5/LG1-3) and a Glu (show DCTN1 Antibodies) residue in the C-terminal tail of chain gamma1 (gamma1-Glu1607) are required for binding to integrins.
The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility.
disruption of the LAMA5 gene dramatically reduced hPSC self-renewal and increased apoptosis without affecting the expression of pluripotency markers.
Gal-1 (show LGALS1 Antibodies) decreased the expression of collagen genes COL3A1 (show COL3A1 Antibodies) and COL5A1 (show COL5A1 Antibodies) but increased the expression of fibronectin (show FN1 Antibodies) and laminin 5.
Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM (show BCAM Antibodies)), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
mechanistic role of laminin-511 in tissue homeostasis
Polymorphisms in LN5 were associated with a reduced level of hemoglobin and neutropenia in non-small cell lung cancer.
PDGF (show PDGFA Antibodies)-BB is not superior to laminin as a potential marker of advanced CP.
Using standard histological analyses and electron microscopy, we characterized the morphology of the external genitalia in Lama5 knockout (LAMA5-KO) mouse embryos during both androgen-independent genital tubercle development and androgen-mediated sexual differentiation
The authors show that the integral endothelial basement membrane component, laminin 511 (laminin alpha5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress.
According to the results, it seems that maternal nicotine exposure may induce abnormal laminin alpha 5 expression which may cause defects in kidney function during life time.
Data suggest that the proper expression of laminin-332 (Lamb3 (show LAMB3 Antibodies)) and laminin-511 (lama5) may regulate appropriate hair morphogenesis.
Laminin alpha 5 (Lama5) mRNA expressions in the lung of newborn in the nicotine treated Exp D1 decreased by 0.63 fold.
crystal structure of laminin alpha5LN-LE1-2 fragment shows the LN domain is a beta (show SUCLA2 Antibodies)-jelly roll with several elaborate insertions; surface loop is required for stable ternary association with the beta- and gamma-short arms in the laminin network
Data provides support for a primary role of laminin-511 and integrin beta-1 (show ITGB1 Antibodies) promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh (show SHH Antibodies) target gene induction.
Downregulation of laminin-511 is important for hair regression.
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
, laminin subunit alpha-5
, unm m538
, laminin, alpha 5
, laminin subunit alpha-5-like
, laminin alpha-5 chain
, laminin-10 subunit alpha
, laminin-11 subunit alpha
, laminin-15 subunit alpha