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Human Laminin alpha 5 ELISA Kit for Sandwich ELISA - ABIN417805
Laudanski, Charkiewicz, Kuzmicki, Szamatowicz, ?wi?tecka, Mroczko, Niklinski: Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis. in European journal of obstetrics, gynecology, and reproductive biology 2013
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data show that the BCAM/LAMA5 system plays a functional role in the metastatic spreading of KRAS-mutant colorectal cancer
Disruption of LAMA4 (show LAMa4 ELISA Kits), LAMA5, and LAMB2 (show LAMB2 ELISA Kits) or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review)
We report here a severe defect of neuromuscular transmission in a consanguineous patient with a homozygous variant in the laminin alpha-5 subunit gene (LAMA5). The variant c.8046C>T (p.Arg2659Trp) is rare and has a predicted deleterious effect. The affected individual, who also carries a rare homozygous sequence variant in LAMA1 (show LAMA1 ELISA Kits), had muscle weakness, myopia, and facial tics
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 (show ITGA3 ELISA Kits) and ITGA2B), collagen ( COL5A1 (show COL5A1 ELISA Kits)), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.
The Laminin-511 consists of alpha5, beta1, and gamma1 chains, of which three laminin globular domains of the alpha5 chain (alpha5/LG1-3) and a Glu (show DCTN1 ELISA Kits) residue in the C-terminal tail of chain gamma1 (gamma1-Glu1607) are required for binding to integrins.
The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility.
disruption of the LAMA5 gene dramatically reduced hPSC self-renewal and increased apoptosis without affecting the expression of pluripotency markers.
Gal-1 (show LGALS1 ELISA Kits) decreased the expression of collagen genes COL3A1 (show COL3A1 ELISA Kits) and COL5A1 (show COL5A1 ELISA Kits) but increased the expression of fibronectin (show FN1 ELISA Kits) and laminin 5.
Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM (show BCAM ELISA Kits)), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
mechanistic role of laminin-511 in tissue homeostasis
Study found that the extracellular matrix protein laminin-511 (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP (show YAP1 ELISA Kits).
Using standard histological analyses and electron microscopy, we characterized the morphology of the external genitalia in Lama5 knockout (LAMA5-KO) mouse embryos during both androgen-independent genital tubercle development and androgen-mediated sexual differentiation
The authors show that the integral endothelial basement membrane component, laminin 511 (laminin alpha5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress.
According to the results, it seems that maternal nicotine exposure may induce abnormal laminin alpha 5 expression which may cause defects in kidney function during life time.
Data suggest that the proper expression of laminin-332 (Lamb3 (show LAMB3 ELISA Kits)) and laminin-511 (lama5) may regulate appropriate hair morphogenesis.
Laminin alpha 5 (Lama5) mRNA expressions in the lung of newborn in the nicotine treated Exp D1 decreased by 0.63 fold.
crystal structure of laminin alpha5LN-LE1-2 fragment shows the LN domain is a beta (show SUCLA2 ELISA Kits)-jelly roll with several elaborate insertions; surface loop is required for stable ternary association with the beta- and gamma-short arms in the laminin network
Data provides support for a primary role of laminin-511 and integrin beta-1 (show ITGB1 ELISA Kits) promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh (show SHH ELISA Kits) target gene induction.
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
, laminin subunit alpha-5
, unm m538
, laminin, alpha 5
, laminin subunit alpha-5-like
, laminin alpha-5 chain
, laminin-10 subunit alpha
, laminin-11 subunit alpha
, laminin-15 subunit alpha