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marvelD3, occludin (show OCLN Proteins), and tricellulin (show MARVELD2 Proteins) define the tight junction-associated MARVEL protein family
MarvelD3 couples tight junctions to the MEKK1 (show MAP3K1 Proteins)-JNK (show MAPK8 Proteins) pathway to regulate cell behavior and survival.
MarvelD3 is transcriptionally downregulated in Snail (show SNAI1 Proteins)-induced epithelial-mesenchymal transition during the progression for the pancreatic cancer.
MarvelD3 co-localises with occludin (show OCLN Proteins) at tight junctions in intestinal and corneal epithelial cells.
As a component of tight junctions, plays a role in paracellular ion conductivity.
MARVEL domain-containing protein 3
, MARVEL (membrane-associating) domain containing 3