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MPP7 (show CHAF1B Proteins) as a novel candidate gene for Primary open angle glaucoma.
The association of MPP7 (show CHAF1B Proteins) single-nucleotide polymorphism rs4317882 gene variant with site-specific bone mineral density was determined.
The Dlg1 (show DLG1 Proteins)-MPP7 (show CHAF1B Proteins)-Mals3 heterotrimer consists of 2 pairs of heterodimeric L27 (show RPL27 Proteins) domains. These 2 dimers are asymmetric due to the large difference between the N- and C-terminal tandem L27 (show RPL27 Proteins) domain of MPP7 (show CHAF1B Proteins).
MPP7 (show CHAF1B Proteins) is a PDZ protein that interacts with human papillomavirus-16 E6 and forms a tripartite complex with LIN7A or LIN7C and DLG1 (show DLG1 Proteins), regulating the stability and localization of DLG1 (show DLG1 Proteins) to cell junctions.
MPP7 (show CHAF1B Proteins) targets to the lateral surface of epithelial cells via its L27N domain, through an interaction with Dlg1 (show DLG1 Proteins).
MPP7 as a novel candidate gene for Primary open angle glaucoma.
Membrane-associated guanylate kinases (MAGUKs) are important adaptor proteins involved in the assembly of protein complexes at sites of cell-cell contact. They are found in synapses, adherens junctions, and tight junctions. All MAGUKs contain at least 1 PDZ domain, an SH3 domain, and a GUK domain, and many contain 1 or 2 L27 domains, which are involved in multimerization of MAGUKs. MPP7 belongs to the p55 stardust subfamily of MAGUKs, which is named for a Drosophila gene required for establishment of cell polarity in the developing fly embryo (Bohl et al., 2007
MAGUK p55 subfamily member 7
, protein humpback