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Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct
co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by Nf2 loss, which can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap (show YAP1 ELISA Kits).
Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP (show YAP1 ELISA Kits) signaling activity.
NF2 is activated by oxidative stress in cardiomyocytes and myocardium and facilitates apoptosis.
loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (show NGFR ELISA Kits)) expression.
Loss of Nf2 and Cdkn2a/b have synergistic effects with PDGF-B (show PDGFB ELISA Kits) overexpression promoting meningioma malignant transformation.
Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation
Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.
Merlin and Ezrin (show EZR ELISA Kits) are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (show EGFR ELISA Kits).
The study describe a novel NF2 mouse model recapitulating schwannoma phenotypes found in human patients where tumors develop in the cranial nerve VIII (show COX8A ELISA Kits) and/or the spinal roots.
Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2 (show ERBB2 ELISA Kits)-dependent manner.
These findings uncover the significance of Merlin protein expression and Survivin (show BIRC5 ELISA Kits) labeling index as prognosticators for poor clinical outcome in two independent Malignant pleural mesothelioma cohorts.
NF2 localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 to TIMAP (show PPP1R16B ELISA Kits) and EBP50 (show SLC9A3R1 ELISA Kits) is critical in nuclear localization of NF2. (NF2 = neurofibromin 2; TIMAP (show PPP1R16B ELISA Kits) = TGF-beta-inhibited membrane-associated protein (show PPP1R16B ELISA Kits); EBP50 (show SLC9A3R1 ELISA Kits) = Ezrin (show EZR ELISA Kits)-Radixin (show RDX ELISA Kits)-Mosein binding phosphoprotein 50)
Low merlin expression is associated with meningioma and schwannoma.
Collectively, we provide for the first time in vivo evidence that the function of Merlin, as a tumor suppressor is independent of its conformational change.
Data show that neurofibromin 2 (Merlin) suppresses proliferation and adhesion, at least partly, through inhibiting kinase suppressor of Ras 1 (KSR1 (show KSR1 ELISA Kits)) and DCAF1 protein.
IL-1beta (show IL1B ELISA Kits) Induces NF2 Promoter Methylation in Meningioma/Leptomeningeal Cells.
The authors proposed that NF2 behaves as a protein sensing tissue damage and aromatase (show CYP19A1 ELISA Kits)-driven local estrogen formation, eventually leading to regulation of stem cells differentiation and tissue repair by liver cancer cells. (Review)
Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2), LATS2 (large tumor suppressor kinase 2), and YAP (show YAP1 ELISA Kits)/TAZ (show TAZ ELISA Kits) (nuclear translocation of complex of Yes-associated protein [YAP (show YAP1 ELISA Kits)] with transcriptional coactivator with PDZ-binding motif (show WWTR1 ELISA Kits) [TAZ (show TAZ ELISA Kits)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.
The mortality of patients with NF2 diagnosed in more recent decades was lower than that of patients diagnosed earlier.
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
neurofibromin 2 (bilateral acoustic neuroma)
, neurofibromatosis 2
, neurofibromin 2
, moesin-ezrin-radixin-like protein
, moesin-ezrin-radixin like
, moesin-ezrin-radizin-like protein