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Nlgn4 KO impairs synaptic inhibition in hippocampal CA3 (show CA3 Proteins) area and perturbs gamma oscillations.
Our findings indicate an absence of autism-relevant behavioral phenotypes in subsequent generations of Nlgn4 mice tested at two locations.
Mice with a loss-of-function mutation in the Nlgn4 exhibit highly selective deficits in reciprocal social interactions and communication that are reminiscent of autism spectrum conditions in humans.
The selectively rapid evolution of NL4 in mice suggests that its function in the brain is under less stringent control than that of other NLs (show ALDH1A2 Proteins).
NLGN4X might represent novel biomarkers and therapeutic targets for breast cancer. Inhibition of NLGN4X may be a new target for the prevention and treatment of breast cancer
Noncoding polymorphisms on NLGN4X may be associated to autism suggesting the key role of NLGN4X in autism pathophysiology and in its male prevalence.
Endogenous NLGN4X is intensely phosphorylated on T707 upon PKC stimulation in human neurons.
Our data provided a further evidence for the involvement of NLGN3 (show NLGN3 Proteins) and NLGN4X gene in the pathogenesis of autism in Chinese population.
The present study explores, for the first time, the contribution of NLGN3 (show NLGN3 Proteins) and NLGN4X genetic variants in Greek patients with autistic disorder.
In vitro models show NLGN4X knockdown directly impacts neurodevelopmental process during the formation of neurons and their connections.
Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population.
Neuroligins are adhesion proteins that bind to beta-neurexin (show NRXN1 Proteins) to form functional synapses.
The autism-associated DeltaE4 mutation in NLGN4 compromises the ability of NLGN4 to localize correctly to the cell surface when overexpressed and to induce synaptic differentiation.
results indicate that the genetic variants located in NLGN4 can affect the cognitive abilities of boys.
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene.
X-linked neuroligin 4
, neuroligin-4, X-linked
, neuroligin 4, X-linked
, neuroligin-4, X-linked-like
, neuroligin 4
, Neuroligin-4, X-linked