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PAK4 (show PAK4 ELISA Kits) phosphorylates Par6B at Ser143 blocking its interaction with Cdc42 (show CDC42 ELISA Kits).
Pard6b is necessary for blastocyst morphogenesis
found that the polarity determinants Cdc42 (show CDC42 ELISA Kits), Par6B, PKCzeta (show PRKCZ ELISA Kits)/iota and the structural proteins ezrin (show EZR ELISA Kits) and phospho-ezrin (show EZR ELISA Kits) were lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in patients
Data conclude that Par6B and aPKC control mitotic spindle orientation in polarized epithelia and, furthermore, that aPKC coordinately regulates multiple processes to promote morphogenesis.
This study demonstrates that controlled regulation of PAK4 (show PAK4 ELISA Kits) is required for apical junction formation in lung epithelial cells and highlights potential cross-talk between two Cdc42 (show CDC42 ELISA Kits) targets, PAK4 (show PAK4 ELISA Kits) and Par6B.
The ability of SRC (show SRC ELISA Kits) family coactivators to regulate the expression of one of these genes, PARD6B/Par6, was confirmed by using cells individually depleted of SRC-1 (show SRC ELISA Kits).
Interaction between PAR-3 (show F2RL2 ELISA Kits) and the aPKC-PAR-6 (show PARD6A ELISA Kits) complex is indispensable for apical domain development of epithelial cells.
Data indicate that the polarity protein Partitioning defective-6 homolog beta (Par6b) regulates not only the dynamics of apicobasal polarity but also integrity of the developing stratified epidermis.
ephrinB1 (show EFNB1 ELISA Kits) associates with the Par (show AFG3L2 ELISA Kits) polarity complex protein Par-6 (show PARD6A ELISA Kits) and can compete with the small GTPase (show RACGAP1 ELISA Kits) Cdc42 (show CDC42 ELISA Kits) for association with Par-6.
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.
par-6 partitioning defective 6 homolog beta (C. elegans)
, PAR-6 beta
, partitioning defective 6 homolog beta
, partitioning-defective protein 6, beta
, par-6 partitioning defective 6 homolog beta
, partitioning defective 6 beta