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PAK4 (show PAK4 Proteins) phosphorylates Par6B at Ser143 blocking its interaction with Cdc42 (show CDC42 Proteins).
Pard6b is necessary for blastocyst morphogenesis
found that the polarity determinants Cdc42 (show CDC42 Proteins), Par6B, PKCzeta (show PRKCZ Proteins)/iota and the structural proteins ezrin (show EZR Proteins) and phospho-ezrin (show EZR Proteins) were lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in patients
Data conclude that Par6B and aPKC control mitotic spindle orientation in polarized epithelia and, furthermore, that aPKC coordinately regulates multiple processes to promote morphogenesis.
This study demonstrates that controlled regulation of PAK4 (show PAK4 Proteins) is required for apical junction formation in lung epithelial cells and highlights potential cross-talk between two Cdc42 (show CDC42 Proteins) targets, PAK4 (show PAK4 Proteins) and Par6B.
The ability of SRC (show SRC Proteins) family coactivators to regulate the expression of one of these genes, PARD6B/Par6, was confirmed by using cells individually depleted of SRC-1 (show SRC Proteins).
Interaction between PAR-3 (show F2RL2 Proteins) and the aPKC-PAR-6 (show PARD6A Proteins) complex is indispensable for apical domain development of epithelial cells.
Data indicate that the polarity protein Partitioning defective-6 homolog beta (Par6b) regulates not only the dynamics of apicobasal polarity but also integrity of the developing stratified epidermis.
ephrinB1 (show EFNB1 Proteins) associates with the Par (show AFG3L2 Proteins) polarity complex protein Par-6 (show PARD6A Proteins) and can compete with the small GTPase (show RACGAP1 Proteins) Cdc42 (show CDC42 Proteins) for association with Par-6.
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.
par-6 partitioning defective 6 homolog beta (C. elegans)
, PAR-6 beta
, partitioning defective 6 homolog beta
, partitioning-defective protein 6, beta
, par-6 partitioning defective 6 homolog beta
, partitioning defective 6 beta