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This paper shows Par6G as a negative regulator of the phosphatidylinositol 3'-kinase/phosphoinositide-dependent protein kinase (show CDK7 Proteins) 1/Akt (show AKT1 Proteins) pathway and epithelial cell proliferation and evidence for frequent inactivation of Par6G gene in epithelial cancers.
this study is the first to identify Par6gamma as a component of the mother centriole and to report a role of a mother centriole protein in the regulation of centrosomal protein composition.
Prkci (show PRKCI Proteins) and its downstream partners, such a Pard6g, direct polarized cell division of luminal myocardial cells to drive trabeculation in the nascent heart.
Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity).
PAR-6 gamma protein
, par-6 partitioning defective 6 homolog gamma
, partitioning defective 6 homolog gamma
, PAR-6 gamma
, partitioning-defective protein 6, alpha