Browse our PVRL4 Proteins (PVRL4)

On www.antibodies-online.com are 18 Poliovirus Receptor-Related 4 (PVRL4) Proteins from 7 different suppliers available. Additionally we are shipping PVRL4 Antibodies (73) and PVRL4 Kits (6) and many more products for this protein. A total of 100 PVRL4 products are currently listed.
Synonyms:
1200017F15Rik, EDSS1, LNIR, nectin-4, PRR4, PVRL4, RGD1559826, si:ch211-155e24.1
list all proteins Gene Name GeneID UniProt
PVRL4 71740 Q8R007
Rat PVRL4 PVRL4 498281  
PVRL4 81607 Q96NY8

PVRL4 Proteins (PVRL4) by Origin

More Proteins for PVRL4 Interaction Partners

Mouse (Murine) Poliovirus Receptor-Related 4 (PVRL4) interaction partners

  1. nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Proteins) by regulating the feedback inhibition of SOCS1 (show SOCS1 Proteins) in the JAK2 (show JAK2 Proteins)-STAT5a (show STAT5A Proteins) signaling pathway

  2. Novel type of cell adhesion apparatus is mediated by Nectin-1 (show PVRL1 Proteins) and Nectin-4. It's implicated in prolactin receptor (show PRLR Proteins) signaling for mammary gland development.

  3. Pvrl1 (show PVRL1 Proteins) is a bona fide target gene of the transcription factor p63 (show CKAP4 Proteins), whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 (show IRF6 Proteins)

  4. Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.

  5. Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin (show PVRL1 Proteins) adhesion molecule (show NCAM1 Proteins).

Human Poliovirus Receptor-Related 4 (PVRL4) interaction partners

  1. High Nectin-4 expression is associated with neoplasms.

  2. We show that Measles virus gains entry into MCF7, DLD (show DLD Proteins)-1, and HTB-20 cancer cells through a PVRL4-mediated macropinocytosis pathway and identified the typical cellular GTPase (show RACGAP1 Proteins) and kinase involved.

  3. nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (show PRLR Proteins) by regulating the feedback inhibition of SOCS1 (show SOCS1 Proteins) in the JAK2 (show JAK2 Proteins)-STAT5a (show STAT5A Proteins) signaling pathway

  4. Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for Triple-negative breast cancers

  5. ADAM17 (show ADAM17 Proteins) and ADAM10 (show ADAM10 Proteins) cleave Nectin-4 and release soluble Nectin-4 (sN4).

  6. The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis

  7. Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.

  8. Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis. This difference was significant in the endometrium of patients having endometriosis.

  9. Transformation of breast cancer cells is dependent on PVRL4.

  10. Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.

PVRL4 Protein Profile

Protein Summary

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Alternative names and synonyms associated with PVRL4

  • poliovirus receptor-related 4 (PVRL4)
  • poliovirus receptor-related 4 (pvrl4)
  • poliovirus receptor-related 4 (LOC100348580)
  • poliovirus receptor-related 4 (Pvrl4)
  • 1200017F15Rik protein
  • EDSS1 protein
  • LNIR protein
  • nectin-4 protein
  • PRR4 protein
  • PVRL4 protein
  • RGD1559826 protein
  • si:ch211-155e24.1 protein

Protein level used designations for PVRL4

poliovirus receptor-related 4 , poliovirus receptor-related protein 4-like , ig superfamily receptor LNIR , nectin 4 , nectin-4 , poliovirus receptor-related protein 4 , Ig superfamily receptor LNIR

GENE ID SPECIES
609931 Canis lupus familiaris
794920 Danio rerio
100032730 Monodelphis domestica
100066309 Equus caballus
100348580 Oryctolagus cuniculus
100435072 Pongo abelii
71740 Mus musculus
498281 Rattus norvegicus
81607 Homo sapiens
507718 Bos taurus
Selected quality suppliers for PVRL4 Proteins (PVRL4)
Did you look for something else?