Browse our anti-SCRIB (SCRIB) Antibodies

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anti-Scribbled Homolog (Drosophila) Antibodies (SCRIB)
On are 25 Scribbled Homolog (Drosophila) (SCRIB) Antibodies from 9 different suppliers available. Additionally we are shipping and SCRIB Kits (1) and many more products for this protein. A total of 29 SCRIB products are currently listed.
0424/05, AI118201, CG5462, CG5467, CG31082, CG42614, CG43398, Crc, CRIB, CRIB1, CT17324, Dmel\\CG43398, Dmel_CG5462, Dmel_CG5467, Dmel_CG31082, Dmel_CG42614, ird, ird15, l(3)673, l(3)c00119, l(3)j7B3, l(3)S042405, MENE (3R)-F, mKIAA0147, Scb, SCR, scrb, SCRB1, Scrib, SCRIB1, scribble, scribble1, si:ch211-12p8.1, si:zc12p8.1, smi97B, vart, Vartul
list all antibodies Gene Name GeneID UniProt
SCRIB 105782 Q80U72
SCRIB 23513 Q14160

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More Antibodies against SCRIB Interaction Partners

Fruit Fly (Drosophila melanogaster) Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. Data suggest that Nrx-1 plays critical roles in regulating synaptic terminal clustering and release of synaptic vesicles of the neuromuscular junction; Nrx-1 controls terminal clustering and release of synaptic vesicles by stimulating presynaptic actin cytoskeleton assembly; Nrx-1 functions via Scribble and Pixie to activate Rac1. (Nrx-1 = neurexin-1; Rac1 = GTP-binding protein Rac1)

  2. the simultaneous loss of the asymmetric cell division regulators Canoe (afadin (show MLLT4 Antibodies) in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption of the asymmetric cell division process and canoe loss-mediated Ras-PI3K-Akt (show AKT1 Antibodies) activation

  3. the effects of loss of scrib and the modification of these effects via cooperative interactions that enhance the overall tumorigenic potential of scrib deficient cells, is reported.

  4. Knocking down scribble expression in either Mushroom body neurons or Dopaminergic neurons impairs normal memory loss.

  5. Our data reveal that the basolateral determinant Scribbled (Scrib) is required for PCV formation through optimizing BMP (show TGFb Antibodies) signaling. Scrib regulates BMP (show TGFb Antibodies)-type I receptor Thickveins (Tkv) localization at the basolateral region of PCV cells and subsequently facilitates Tkv internalization to Rab5 (show RAB5A Antibodies) endosomes, where Tkv is active

  6. Scrib module regulates epithelial polarity by influencing endocytic itineraries of Crumbs and other retromer-dependent cargo.

  7. Loss of scrib, dlg (show DLG4 Antibodies) and lgl had no effect on gonad formation, but Dlg (show DLG4 Antibodies) and Scrib in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.

  8. Drosophila scrib acts downstream of the Fat (Ft) receptor, and requires Hippo signaling for its growth regulatory functions.

  9. Loss of Scrib promotes Yorkie (show YAP1 Antibodies)/Scalloped-dependent epithelial tissue overgrowth, and this is also important for driving cooperative tumor overgrowth with oncogenic Ras-Raf (show RAF1 Antibodies) signaling.

  10. Data show that mutations causing the loss of Salvador (Sav (show SAV1 Antibodies)) or Scribble (Scrib) or activation of Ras transform normal stem cells into cancer stem cells through a multistep process in the adult Drosophila Malpighian tubules.

Mouse (Murine) Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy.

  2. Suggest a role for Plexin-B1 (show PLXNB1 Antibodies) as a ligand and Sema4A (show Sema4a Antibodies) as a receptor and characterize a reverse signaling pathway downstream of Sema4A (show Sema4a Antibodies) regulating cell migration via Scrib.

  3. SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages

  4. we provide genetic evidence of a unique link between skin carcinogenesis and loss of the epithelial polarity regulator Scrib, emphasizing that Scrib exerts a wide-spread tumor suppressive function in epithelia.

  5. The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

  6. Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate.

  7. Scrib is a novel proinflammatory regulator in endothelial cells, which maintains the protein expression of GATA-like protein-1 (show ZGLP1 Antibodies).

  8. The Scrib-Rac1 interaction plays a crucial role in the organization of developing cardiomyocytes and formation of the ventricular myocardium.

  9. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors

  10. findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK (show MAPK1 Antibodies)/Fra1 (show FOSL1 Antibodies) pathway that alters mammary progenitor activity

Zebrafish Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA (show COPA Antibodies)) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 (show VANGL2 Antibodies) and Scribble both prior to and after midline crossing; experiments establish CoPA (show COPA Antibodies) axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance.

  2. Zygotic expression of Scribble1 (scrb1) is required for migration of the nVII motor neurons mainly in a non cell-autonomous manner, while maternal expression is required for convergent extension movements during gastrulation.

  3. Suppression of scrib and puf60 in zebrafish (show PUF60 Antibodies)leads to reduction in body length, small head size, and craniofacial defects.

  4. It was found that Scribble is required for oriented cell division and that its function in this process is independent of canonical apicobasal and planar polarity pathways.

  5. Lpp interacts with the PCP (show PRCP Antibodies) protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension.

  6. Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates

Human Scribbled Homolog (Drosophila) (SCRIB) interaction partners

  1. a new function for Scribble in Rho regulation that entails positioning of DLC3 (show STARD8 Antibodies) GAP activity at cell junctions in polarized epithelial cells, is reported.

  2. Low Scribble expression in the primary breast tumor was correlated to prognosis in estrogen receptor (show ESR1 Antibodies)-positive breast cancer patients.

  3. Suggest a role for Plexin-B1 (show PLXNB1 Antibodies) as a ligand and Sema4A (show Sema4a Antibodies) as a receptor and characterize a reverse signaling pathway downstream of Sema4A (show Sema4a Antibodies) regulating cell migration via Scrib.

  4. SCRIB uncouples reactive oxygen species-dependent bacterial killing activity from M1 polarization and inflammatory functions of macrophages

  5. The Palmitoylation-deficient mutants of SCRIB were mislocalized, leading to disruption of cell polarity and loss of their tumor-suppressive activities to oncogenic YAP (show YAP1 Antibodies), MAPK (show MAPK1 Antibodies) and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathways.

  6. Data show hepatitis C virus (HCV) nonstructural protein 4B (NS4B) PDZ (show INADL Antibodies)-binding motif (PBM) promotes the colony formation of hepatoma cells by degrading human Scribble protein.

  7. the inclusion/exclusion of specific SCRIB exons is a mechanistic hallmark of breast cancer, which could potentially be exploited to develop more efficient diagnostics and therapies.

  8. loss of Scribble-induced HuR (show ELAVL1 Antibodies) translocation mediates the accumulation of Snail (show SNAI1 Antibodies) via activation of the p38 MAPK (show MAPK14 Antibodies) pathway.

  9. The two PDZ (show INADL Antibodies) domains within the PDZ34 tandem of Scribble, a cell polarity regulator, tightly pack in a 'front-to-back' mode to form a compact supramodule.

  10. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors

SCRIB Antigen Profile

Antigen Summary

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Alternative names and synonyms associated with SCRIB

  • scribbled (scrib) antibody
  • scribbled homolog (Drosophila) (Scrib) antibody
  • scribbled homolog (Drosophila) (scrib) antibody
  • scribbled planar cell polarity protein (SCRIB) antibody
  • 0424/05 antibody
  • AI118201 antibody
  • CG5462 antibody
  • CG5467 antibody
  • CG31082 antibody
  • CG42614 antibody
  • CG43398 antibody
  • Crc antibody
  • CRIB antibody
  • CRIB1 antibody
  • CT17324 antibody
  • Dmel\\CG43398 antibody
  • Dmel_CG5462 antibody
  • Dmel_CG5467 antibody
  • Dmel_CG31082 antibody
  • Dmel_CG42614 antibody
  • ird antibody
  • ird15 antibody
  • l(3)673 antibody
  • l(3)c00119 antibody
  • l(3)j7B3 antibody
  • l(3)S042405 antibody
  • MENE (3R)-F antibody
  • mKIAA0147 antibody
  • Scb antibody
  • SCR antibody
  • scrb antibody
  • SCRB1 antibody
  • Scrib antibody
  • SCRIB1 antibody
  • scribble antibody
  • scribble1 antibody
  • si:ch211-12p8.1 antibody
  • si:zc12p8.1 antibody
  • smi97B antibody
  • vart antibody
  • Vartul antibody

Protein level used designations for SCRIB

CG43398-PA , CG43398-PB , CG43398-PC , CG43398-PD , CG43398-PH , CG43398-PI , CG43398-PJ , CG43398-PK , CG43398-PL , CG43398-PM , CG43398-PN , CG43398-PO , CG43398-PP , CG43398-PQ , CG43398-PR , CG43398-PS , CG43398-PT , CG43398-PU , CG43398-PX , gp150-like , immune response deficient 15 , lethal (3) c00119 , scrib-PA , scrib-PB , scrib-PC , scrib-PD , scrib-PH , scrib-PI , scrib-PJ , scrib-PK , scrib-PL , scrib-PM , scrib-PN , scrib-PO , scrib-PP , scrib-PQ , scrib-PR , scrib-PS , scrib-PT , scrib-PU , scrib-PX , scribble , scribbles , smell impaired 97B , vartul , PDZ-domain protein scribble , circletail , protein scribble homolog , scribble homolog 1 , landlocked , llk , scribbled homolog

44448 Drosophila melanogaster
105782 Mus musculus
368473 Danio rerio
23513 Homo sapiens
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