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tau is a good substrate for PSK1 and PSK2 (show TAOK1 ELISA Kits) phosphorylation with mass spectrometric analysis of phosphorylated tau revealing more than 40 tau residues as targets of these kinases.
TAOK2 is essential for dendrite morphogenesis; TAOK2 downregulation impairs basal dendrite formation without affecting apical dendrites.
PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity
mediates signaling from carbachol to p38 mitogen-activated protein kinase (show MAPK14 ELISA Kits) and ternary complex factors
the TAK1 (show MAP3K7 ELISA Kits)-JNK (show MAPK8 ELISA Kits) pathway is activated by osmotic stress, while blocking TAK1 (show MAP3K7 ELISA Kits)-mediated NF-kappaB (show NFKB1 ELISA Kits) activation; TAO2 regulates TAK1 (show MAP3K7 ELISA Kits) pathways
PSK1-alpha is a bifunctional kinase that associates with microtubules, and JNK- and caspase-mediated removal of its C-terminal microtubule-binding domain permits nuclear translocation of the N-terminal region of PSK1-alpha and its induction of apoptosis
disruption of the Taok2 gene alters behavioral response to ethanol.
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
TAO kinase 2
, serine/threonine-protein kinase TAO2
, serine/threonine-protein kinase TAO2-like
, kinase from chicken homolog C
, prostate derived STE20-like kinase PSK
, prostate-derived STE20-like kinase 1
, prostate-derived sterile 20-like kinase 1
, thousand and one amino acid protein kinase 2
, TAO kinase 2TAO kinase 2
, thousand and one amino acid protein 2
, serine-threonine kinase
, serine/threonine protein kinase TAO2