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anti-Human Vinculin Antibodies:
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Human Polyclonal Vinculin Primary Antibody for IF (cc), IF (p) - ABIN719261
Li, Sun, Yang, Hu, Jiang: Tanshinone II a protects against lipopolysaccharides-induced endothelial cell injury via Rho/Rho kinase pathway. in Chinese journal of integrative medicine 2014
Show all 6 Pubmed References
Human Polyclonal Vinculin Primary Antibody for IHC (p), WB - ABIN3044168
Lyu, Wang, Wang, Ding, Liu, Yuan, Shi, Wang, Wang, Chen: Maintaining the pluripotency of mouse embryonic stem cells on gold nanoparticle layers with nanoscale but not microscale surface roughness. in Nanoscale 2014
Show all 3 Pubmed References
Chicken Monoclonal Vinculin Primary Antibody for IHC (fro), WB - ABIN3043674
Lyu, Hu, Xu, Zhang: Dynamics of focal adhesions and reorganization of F-actin in VEGF-stimulated NSCs under varying differentiation states. in Journal of cellular biochemistry 2013
Show all 3 Pubmed References
Amphibian Monoclonal Vinculin Primary Antibody for ICC, IHC (fro) - ABIN269480
Chianale, Cutrupi, Rainero, Baldanzi, Porporato, Traini, Filigheddu, Gnocchi, Santoro, Parolini, van Blitterswijk, Sinigaglia, Graziani: Diacylglycerol kinase-alpha mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling. in Molecular biology of the cell 2007
Show all 4 Pubmed References
Bat Polyclonal Vinculin Primary Antibody for WB - ABIN611567
Hou, Schindler, Henzel, Ho, Brasseur, McKnight: An interleukin-4-induced transcription factor: IL-4 Stat. in Science (New York, N.Y.) 1994
Show all 3 Pubmed References
Mouse (Murine) Monoclonal Vinculin Primary Antibody for IHC (fro), IHC (p) - ABIN289630
Witt, Zieseniss, Fock, Jockusch, Illenberger: Comparative biochemical analysis suggests that vinculin and metavinculin cooperate in muscular adhesion sites. in The Journal of biological chemistry 2004
Human Monoclonal Vinculin Primary Antibody for IP, IHC - ABIN284839
Korte, Fröhlich, Kohn, Kaspers, Arnold, Härtle: 2-D DIGE analysis of the bursa of Fabricius reveals characteristic proteome profiles for different stages of chicken B-cell development. in Proteomics 2012
Human Monoclonal Vinculin Primary Antibody for IF, ELISA - ABIN563365
Maghdessian, Côté, Rouleau, Ben Djoudi Ouadda, Levy, Lavoie: Ascorbylperoxide contaminating parenteral nutrition perturbs the lipid metabolism in newborn guinea pig. in The Journal of pharmacology and experimental therapeutics 2010
Study used an all-heavy-atom structure-based model to study vinculin activation by talin in a high-tension context mechanically driven by F-actin, showed that vinculin activation may proceed from an intermediate state stabilized by partial talin-vinculin association. There is a low-force regime and a high-force regime where vinculin activation is dominated by two different pathways with distinct responses to force.
Vinculin head-tail interaction is required on soft substrates to destabilize vinculin and talin in FAs (show FAS Antibodies), and to allow hMSCs branching. Another module involves paxillin (show PXN Antibodies) and FAK (show PTK2 Antibodies), which soft substrates also destabilize, but independently of vinculin head-tail interaction. This multi-modularity may be key to allow a versatile response to complex biomechanical cues.
The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM (show MMRN1 Antibodies) interactions and remodeling of the tissue.
East Asian common VCL variant p.Asp841His (D841H) was associated with sudden unexplained nocturnal death syndrome (SUNDS) in the Chinese Han population.
We identified mutations in VCL associated with Short segment Hirschsprung disease. Correction of this mutation in induced pluripotent stem cells using CRISPR/Cas9 editing, as well as the RET (show RET Antibodies) G731del mutation that causes Hirschsprung disease with total colonic aganglionosis, restored enteric neural crest cell function.
This review discusses the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. [review]
Study predicted the structure of the MAPK1 (show MAPK3 Antibodies)-vinculin binding interface using a combination of flexible docking and molecular dynamics simulations, and confirmed that the MAPK1 (show MAPK3 Antibodies)-vinculin interaction is mechanically regulated, and implicated a change in the vinculin D3-D4 cleft size upon vinculin activation as the basis for the conformational selectivity of MAPK1 (show MAPK3 Antibodies) binding toward open vinculin.
These results suggest that vinculin promotes the nuclear localization of transcription factor TAZ (show TAZ Antibodies) to inhibit the adipocyte differentiation on rigid extracellular matrix.
The VCL-encoding protein was involved in cardiomyopathy that associated with hypertension, therefore our results suggest the rs4746172 of VCL may be a novel target for clinical interventions to reduce CVD risk by regulating blood pressure in male Chinese
Three novel genes were identified as recurrently mutated; MYCN (show MYCN Antibodies), MYO5B and VCL, and mutations in these genes were exclusively found in malignant sympathetic paraganglioma tumors.
Study show that zebrafish contain two homologous vinculin isoforms, of which the sequence of key functional domains is conserved with several higher vertebrate. Loss of both zygotic vcla and maternal contribution of vcla did not result in notable defects, while the additional loss of zygotic vclb is lethal only after embryonic stages. These data indicate that embryonic development in zebrafish can occur without vinculin.
Results suggest that myosin VI (show MYO6 Antibodies) and vinculin form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.
Lipid binding increases vinculin activation and turnover at focal adhesions.
results suggest that the vinculin-actin interaction participates in FA-mediated mechanotransduction
The results indicate that lipid rafts play an important role in extracellular matrix stiffness regulation of cell migration via expression vinculin and its interaction with vinexin alpha (show Sorbs3 Antibodies).
Binding of vinculin to the R1-R3 region of the talin rod is important for focal adhesion stability.
These data demonstrate that Src-mediated phosphorylation is necessary for vinculin activation, and that phosphorylation controls cytoskeletal mechanics by regulating force transmission between the actin cytoskeleton and focal adhesion proteins.
results suggest that vinculin promotes directionally persistent cell migration and tension-dependent ECM (show MMRN1 Antibodies) remodeling in complex 3D environments by increasing cell-ECM (show MMRN1 Antibodies) adhesion and traction force generation.
Force-dependent conformational switch of alpha-catenin (show CTNNA1 Antibodies) controls vinculin binding.
Mutant vinculin expressing cells are altered in cell migration, which is accompanied by changes in cell adhesion.
show that Src (show SRC Antibodies) phosphorylation of Y1065 within the C-terminal hairpin regulates Vt-mediated actin bundling and provide a detailed characterization of vinculin Y1065 mutations
These findings demonstrate the crucial importance of the tight control of the activity of vinculin.
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
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